Freeze-Drying of Platelet-Rich Plasma: The Quest for Standardization
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In this article, the authors present the current state of experimental and clinical platelet-rich plasma (FD-PRP) research in different medical areas in which PRP has potential to meet prevailing medical needs.Abstract:
The complex biology of platelets and their involvement in tissue repair and inflammation have inspired the development of platelet-rich plasma (PRP) therapies for a broad array of medical needs. However, clinical advances are hampered by the fact that PRP products, doses and treatment protocols are far from being standardized. Freeze-drying PRP (FD-PRP) preserves platelet function, cytokine concentration and functionality, and has been proposed as a consistent method for product standardization and fabrication of an off-the-shelf product with improved stability and readiness for future uses. Here, we present the current state of experimental and clinical FD-PRP research in the different medical areas in which PRP has potential to meet prevailing medical needs. A systematic search, according to PRISMA (Preferred Reported Items for Systematic Reviews and Meta-Analyses) guidelines, showed that research is mostly focused on wound healing, i.e., developing combination products for ulcer management. Injectable hydrogels are investigated for lumbar fusion and knee conditions. In dentistry, combination products permit slow kinetics of growth factor release and functionalized membranes for guided bone regeneration.read more
Citations
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Lyophilised Platelet-Rich Fibrin: Physical and Biological Characterisation
Nurul Aida Ngah,George J. Dias,Darryl C. Tong,Siti Noor Fazliah Mohd Noor,Jithendra Ratnayake,Paul R. Cooper,Haizal Mohd Hussaini +6 more
TL;DR: In this paper, a lyophilized platelet-rich fibrin (Ly-PRF) was used for craniofacial tissue engineering purposes, and the results showed a dense and homogeneous interconnected 3D fibrins network with morphologically consistent cells of platelets and leukocytes.
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Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review
TL;DR: An overview of biopolymers’ roles in wound physiology is provided as a perspective on the development of a new generation of enhanced, naturally inspired, smart wound dressings based on blood products, stem cells and growth factors.
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A Pilot Clinical Study of Hyperacute Serum Treatment in Osteoarthritic Knee Joint: Cytokine Changes and Clinical Effects.
Isabel Olmos Calvo,Eszter Fodor,Dorottya Kardos,István Hornyák,Adél Hinsenkamp,Olga Kuten-Pella,Zsuzsanna Gyevnár,Gábor Erdélyi,Tamás Bárdos,Tamás Mirkó Paukovits,Krisztián Magos,György Béres,Stefan Nehrer,Zsombor Lacza +13 more
TL;DR: Hyperacute serum has a positive effect in alleviating symptoms of osteoarthritic knees and identified protein clusters may allow the prediction of protein expression, reducing the number of investigated proteins in future studies.
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Potential of Lyophilized Platelet Concentrates for Craniofacial Tissue Regenerative Therapies.
Nurul Aida Ngah,Jithendra Ratnayake,Paul R. Cooper,George J. Dias,Darryl C. Tong,Siti Noor Fazliah Mohd Noor,Haizal Mohd Hussaini +6 more
TL;DR: The use of platelet concentrates (PCs) in oral and maxillofacial surgery, periodontology, and craniofacial surgery has been reported as mentioned in this paper.
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Growth Factor Applied to Oral and Regenerative Surgery.
TL;DR: This work will bring to light the current clinical-surgical orientations and the different perspectives in oral surgery, despite that the literature still seems controversial regarding the actual advantages of their use.
References
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