Frequency of Gestational Diabetes Mellitus at Collaborating Centers Based on IADPSG Consensus Panel–Recommended Criteria The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study
David A. Sacks,David R. Hadden,Michael Maresh,Chaicharn Deerochanawong,Alan R. Dyer,Boyd E. Metzger,Lynn P. Lowe,Donald R. Coustan,Moshe Hod,Jeremy Oats,Bengt Persson,Elisabeth R. Trimble +11 more
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TLDR
Although the new diagnostic criteria for GDM apply globally, center-to-center differences occur in GDM frequency and relative diagnostic importance of fasting, 1-h, and 2-h glucose levels, which may impact strategies used for the diagnosis.Abstract:
OBJECTIVE To report frequencies of gestational diabetes mellitus (GDM) among the 15 centers that participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study using the new International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria. RESEARCH DESIGN AND METHODS All participants underwent a 75-g oral glucose tolerance test between 24 and 32 weeks’ gestation. GDM was retrospectively classified using the IADPSG criteria (one or more fasting, 1-h, or 2-h plasma glucose concentrations equal to or greater than threshold values of 5.1, 10.0, or 8.5 mmol/L, respectively). RESULTS Overall frequency of GDM was 17.8% (range 9.3–25.5%). There was substantial center-to-center variation in which glucose measures met diagnostic thresholds. CONCLUSIONS Although the new diagnostic criteria for GDM apply globally, center-to-center differences occur in GDM frequency and relative diagnostic importance of fasting, 1-h, and 2-h glucose levels. This may impact strategies used for the diagnosis of GDM.read more
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Journal ArticleDOI
Prevalence of Gestational Diabetes and Risk of Progression to Type 2 Diabetes: a Global Perspective.
Yeyi Zhu,Cuilin Zhang +1 more
TL;DR: This work comprehensively reviewed available data in the past decade in an attempt to estimate the contemporary global prevalence of gestational diabetes mellitus by country and region and the risk of progression from GDM to T2DM.
Journal ArticleDOI
Gestational diabetes mellitus.
H. David McIntyre,Patrick M. Catalano,Cuilin Zhang,Gernot Desoye,Elisabeth R. Mathiesen,Peter Damm +5 more
TL;DR: Gestational diabetes mellitus is the most common complication in pregnancy and has short-term and long-term effects in both mother and offspring, and dietary modification and increased physical activity are the primary treatments, but pharmacotherapy, usually insulin, is used when normoglycaemia is not achieved.
Journal ArticleDOI
Gestational diabetes and pregnancy outcomes - a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria
Eliana Marcia Wendland,Maria Regina Torloni,Maicon Falavigna,Janet Trujillo,Maria Alice Souza de Oliveira Dode,Maria Amélia Alves de Campos,Bruce Bartholow Duncan,Maria Inês Schmidt +7 more
TL;DR: The WHO and the IADPSG criteria for GDM identified women at a small increased risk for adverse pregnancy outcomes, but full evaluation of the latter in settings other than HAPO requires additional studies.
Journal ArticleDOI
Gestational diabetes mellitus: risks and management during and after pregnancy
TL;DR: Lifestyle modification is the primary approach; use of medications for diabetes prevention after GDM remains controversial and family planning enables optimization of health in subsequent pregnancies.
Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy
Mukesh M. Agarwal,Michel Boulvain,Edward J. Coetzee,Stephen Colagiuri,Maicon Falavigna,Moshe Hod,Sara Meltzer,Boyd E. Metzger,Yasue Omori,Ingvars Rasa,Maria Inês Schmidt,Veerasamy Seshiah,David Simmons,Eugene Sobngwi,Maria Regina Torloni,Huixia Yang +15 more
TL;DR: Each health service will need to assess their burden of hyperglycaemia in pregnancy and decide if and how it will implement programmes to test for and treat such women.
References
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Journal ArticleDOI
Hyperglycemia and adverse pregnancy outcomes
Boyd E. Metzger,Lynn P. Lowe,Alan R. Dyer,Elisabeth R. Trimble,Udom Chaovarindr,Donald R. Coustan,David R. Hadden,David R. McCance,Moshe Hod,Harold David McIntyre,Jeremy Oats,Bengt Persson,Michael S. Rogers,David A. Sacks +13 more
TL;DR: The results indicate strong, continuous associations of maternal glucose levels below those diagnostic of diabetes with increased birth weight and increased cord-blood serum C-peptide levels.
Journal ArticleDOI
International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.
Pregnancy Study Groups Consensus Panel,Boyd E. Metzger,Steven G. Gabbe,Bengt Persson,Thomas A. Buchanan,Patrick A Catalano,Peter Damm,Alan R. Dyer,Alberto de Leiva,Moshe Hod,John L Kitzmiler,Lynn P. Lowe,H. David McIntyre,Jeremy Oats,Yasue Omori,Maria Inês Schmidt +15 more
TL;DR: The Brazilian study provided evidence that adverse perinatal outcomes are associated with levels of maternal glycemia below those diagnostic of GDM by American Diabetes Association or World Health Organization criteria, however, the results were potentially confounded by the treatment of G DM.
Journal ArticleDOI
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Associations with Neonatal Anthropometrics
Boyd E. Metzger,Lynn P. Lowe,Alan R. Dyer,Elisabeth R. Trimble,Brian Sheridan,Moshe Hod,Rony Chen,Yariv Yogev,Donald R. Coustan,Patrick M. Catalano,Warwick B. Giles,Julia Lowe,David R. Hadden,Bengt Persson,Jeremy Oats +14 more
TL;DR: Findings confirm the link between maternal glucose and neonatal adiposity and suggest that the relationship is mediated by fetal insulin production and that the Pedersen hypothesis describes a basic biological relationship influencing fetal growth.
Hyperglycemia and Adverse Pregnancy Outcomes The HAPO Study Cooperative Research Group
TL;DR: Strong, continuous associations of maternal glucose levels below those diagnostic of diabetes with increased birth weight and increased cord-blood serum C-peptide levels are indicated.
Journal ArticleDOI
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations of maternal A1C and glucose with pregnancy outcomes.
Lynn P. Lowe,Boyd E. Metzger,Alan R. Dyer,Julia Lowe,David R. McCance,Terence R.J. Lappin,Elisabeth R. Trimble,Donald R. Coustan,David R. Hadden,Moshe Hod,Jeremy Oats,Bengt Persson +11 more
TL;DR: It is suggested that A1C measurement is not a useful alternative to an OGTT in pregnant women on the basis of associations with adverse outcomes.
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