Journal ArticleDOI
Functional and structural changes after disuse of human muscle.
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TLDR
The discrepancy between the magnitude of the difference observed in the gross measurement of leg function (maximum oxygen uptake) and structure (leg volume) as compared with the cellular level (cross-sectional fibre area) is discussed.Abstract:
1. Seven patients who had suffered unilateral leg fracture were studied after removal of immobilizing plaster casts. 2. Leg volume measured anthropometrically was reduced by 12% in the injured leg (5-68 +/- 1-05 litres) compared with the uninjured (6-43 +/- 0-87 litres). Associated with this loss was a similar reduction in the net maximum oxygen uptake achieved in one-leg cycling, from 1-89 +/- 0-21 1/min in the uninjured leg to 1-57 +/- 0-18 1/min in the injured. 3. Measured by a percutaneous needle biopsy technique, a reduction of 42% was found in the cross-sectional area of the muscle fibres sampled from the vastus lateralis of the injured compared with the uninjured leg. 4. Staining for myosin adenosine triphosphatase activity showed that both type I and II fibres were affected, being reduced respectively from 3410 to 1840 micronm2 and from 3810 to 2390 micronm2 cross-sectional area. 5. Possible reasons and implications are discussed for the discrepancy between the magnitude of the difference observed in the gross measurement of leg function (maximum oxygen uptake) and structure (leg volume) as compared with the cellular level (cross-sectional fibre area).read more
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Skeletal Muscle Adaptability: Significance for Metabolism and Performance
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Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders
TL;DR: The results emphasize the need for an integrative approach in the assessment and therapeutic management of exercise intolerance, which considers the contribution of muscle weakness to excessive symptoms and reduced work capacity, in addition to the contributions of ventilatory, gas exchange, and circulatory impairments.
Journal ArticleDOI
Histochemical and morphological characteristics of the vastus lateralis muscle in patients with chronic obstructive pulmonary disease
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Journal ArticleDOI
Changes in musculoskeletal structure and function with prolonged bed rest.
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References
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Journal ArticleDOI
Data on the distribution of fibre types in thirty-six human muscles: An autopsy study
TL;DR: In this paper, the mean fibre type proportions of each muscle were examined and the spatial distribution of the fibre types was examined in order to determine whether this was random or not, and the number of closed fibers observed in the actual samples was compared statistically with the number expected to occur in a hexagonal lattice model, assuming a random distribution.
Journal ArticleDOI
Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values.
TL;DR: Variation in muscle content of ATP, ATP + ADP + AMP, phosphorylcreatine (PC), creatine (Cr), PC + Cr, and glycogen, between legs, between sites on the same muscle, or as a result of error introduced during analysis, was small compared with the between-individuals variance.
Journal ArticleDOI
Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
TL;DR: In this article, a percutaneous needle biopsy of skeletal muscle in Physiological and Clinical Research is described, and the authors present a detailed discussion of the procedure and the results.
Muscle electrolytes in man determined by neutron activation analysis on needle biopsy specimens
TL;DR: Methods are described whereby very small amounts of alkali and other metals may be accurately assayed in minute tissue samples by submitting them to a neutron flux and, after suitable decay periods, measuring certain isotopes so formed.