Journal ArticleDOI
Functional significance of white blood cells in the male and female reproductive tract
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TLDR
With the advent of modern techniques, e.g. monoclonal antibodies and sophisticated sperm function tests, many of the questions raised should be answered in the near future.Abstract:
The functional significance of white blood cells in the modulation of an anti-sperm antibody response, prevention of infection (including HIV) sperm transport/storage and sperm function is extensively discussed. A critical review of the existing literature is presented with future experimental lines of investigation outlined. A lack of controlled clinical studies in the human to validate data from animal species--for example--the involvement of white blood cells in the transport and storage of sperm in the female tract and the possible adverse effect of pathology (i.e. endometriosis) on these functions are presented. In conclusion, with the advent of modern techniques, e.g. monoclonal antibodies and sophisticated sperm function tests, many of the questions raised should be answered in the near future.read more
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Journal ArticleDOI
The biologic significance of white blood cells in semen.
Edward E. Wallach,Hans Wolff +1 more
TL;DR: There is ample evidence that WBC can affect sperm function and further studies are needed to define cofactors that increase or decrease the risk of sperm damage by WBC.
Journal ArticleDOI
Infections in the male genital tract and reactive oxygen species
TL;DR: There are many unresolved questions concerning the exact role of ROS during infections of the male genital tract because of the difficulty of specifically assessing the site of generation and the short-lived effects of ROS.
Journal ArticleDOI
Seminal tract infections: impact on male fertility and treatment options
TL;DR: Only recently have amplification methods been established to detect viruses in semen with high sensitivity and specificity, and it is unclear if these infections significantly contribute to male infertility.
Journal ArticleDOI
Molecular biology of human male infertility: Links with aging, mitochondrial genetics, and oxidative stress?
Journal ArticleDOI
Differential contribution of leucocytes and spermatozoa to the generation of reactive oxygen species in the ejaculates of oligozoospermic patients and fertile donors.
TL;DR: The results emphasize the importance of spermatozoa as a major source of reactive oxygen species in oligozoospermia and have implications for the diagnosis and treatment of this condition, as well as for the design of appropriate diagnostic strategies.
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