Christopher L.R. Barratt

TL;DR: Beckwith-Wiedemann syndrome is a model imprinting disorder resulting from mutations or epimutations affecting imprinted genes on chromosome 11p15.5 and a clear association between monozygotic twinning and BWS with KvDMR1 loss of methylation was shown.

TL;DR: Four ZP genes are expressed in human oocytes and preliminary data show that the four corresponding ZP proteins are present in the human ZP, which is a fundamental difference with the mouse model.

TL;DR: Oral administration of vitamin E significantly improves the in vitro function of human spermatozoa as assessed by the zona binding test in a double-blind randomized placebo cross-over controlled trial.

TL;DR: This document presents a synthesis of the working group's understanding of the recent literature and collective discussions on the current state of knowledge of sperm chromatin structure and function during fertilization, highlighting the biological, assay and clinical uncertainties that require further research and ends with a series of 5 key recommendations.

TL;DR: The consensus guideline methodology is described, the evidence-based recommendations provided to the World Health Organization for their consideration in the development of global guidance are summarized and a narrative review of the diagnosis of male infertility as related to the eight prioritized PICO questions is presented.