Further observations on the hairpin-tail (Thp) mutation in the mouse
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TLDR
This fact that the phenotype of heterozygous offspring depends on which parent contributed the T hp is offered using the t h2 allele of T as a marker, and possible modes of action of the hairpin allele are discussed.Abstract:
The hairpin-tail allele (Thp) of brachyury (T) on chromosome 17 of the mouse is unique in that the phenotype of heterozygous offspring depends on which parent contributed the Thp.The present paper offers formal proof of this fact using the th2 allele of T as a marker, and discusses possible modes of action of the hairpin allele.read more
Citations
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Role of Insulin-like Growth Factors in Embryonic and Postnatal Growth
TL;DR: Postnatal growth curves indicated that surviving Igf-1(-/-) mutants, which are infertile and exhibit delayed bone development, continue to grow with a retarded rate after birth in comparison with wild-type littermates and become 30% of normal weight as adults.
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Parental imprinting of the mouse insulin-like growth factor II gene
TL;DR: It is demonstrated that IGF-II is indispensable for normal embryonic growth and that the IGF- II gene is subject to tissue-specific parental imprinting.
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The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus
TL;DR: It is reported here that the genes for insulin-like growth factor type-2 receptor (Igf 2r) and mitochondrial superoxide dismutase-2 (Sod-2) are absent from both deletions, and that Igf2r is imprinted and closely linked or identical to Tme.
Journal ArticleDOI
Differential activity of maternally and paternally derived chromosome regions in mice
B.M. Cattanach,Maggie Kirk +1 more
TL;DR: It is reported that animals with maternal duplication/paternal deficiency and its reciprocal for each of two particular chromosome regions show anomalous phenotypes which depart from normal in opposite directions, suggesting a differential functioning of gene loci within these regions.
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Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.
Hiroyuki Sasaki,Peter A. Jones,Peter A. Jones,J R Chaillet,Anne C. Ferguson-Smith,S.C. Barton,Wolf Reik,M.A. Surani +7 more
TL;DR: It is shown that the chromatin of the 5' region of the repressed Igf2 allele is potentially active for transcription rather than heterochromatic, and parental methylation differences in a region several kilobases upstream of the first exon are observed.
References
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An air-drying method for meiotic preparations from mammalian testes.
TL;DR: The air-drying method gives improved spreading of the chromosomes and less cell breakage compared with squash techniques, suitable for stages of male meiosis in which the chromosomes are condensed.
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The genetics of the mammalian gamete
TL;DR: Study of the association of the somatic and gametic genotypes with the gametic phenotype has been termed the genetics of gametes.
Journal ArticleDOI
Hairpin-tail: a case of post-reductional gene action in the mouse egg.
TL;DR: Hairpin-tail (T(hp)) is a new allele of brachyury on chromosome 17 (linkage group IX) of the mouse and the morphological effects in the heterozygote are on the notochord and the tail.
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Expression of paternal glucose phosphate isomerase-1 (Gpi-1) in preimplantation stages of mouse embryos.
TL;DR: These findings indicate that the Gpi-1 paternal locus is expressed by day 5, and demonstrate the value of using electrophoretic variants to pinpoint synthesis of new enzyme which may not be reflected in changes in levels of activity.
Journal ArticleDOI
Expression of the mammalian x chromosome before and after fertilization.
TL;DR: The results indicate that the X-linked enzyme lacuts is expressed after fertilization but before the morula stage, and that inactivation of the X chromosome does not occur during oogenesis.
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