Journal ArticleDOI
GABA receptors: are cellular differences reflected in function?
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TLDR
It is proposed that GABAA and GABAB receptors differ not only at the cellular level, but that they also have different functions in the mammalian central nervous system.About:
This article is published in Brain Research Reviews.The article was published on 1989-07-01. It has received 183 citations till now. The article focuses on the topics: GABAA-rho receptor & GABAB receptor.read more
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Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance.
TL;DR: The abundant CNS cholesterol and its sulfate derivative serve as precursors of different neurosteroids, which bidirectionally modulate neuronal excitability, by potentiating or inhibiting function of the GABAA receptors.
Journal ArticleDOI
GABA receptor mechanisms in the central nervous system.
Lucia G. Sivilotti,A. Nistri +1 more
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Localization of a memory trace in the mammalian brain
TL;DR: The rabbit eyeblink response was classically conditioned while regions of the cerebellum or red nucleus were temporarily inactivated by microinfusions of the gamma-aminobutyric acid agonist muscimol, and the site of memory formation for this learned response appears to be localized within the Cerebellum.
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A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.
TL;DR: It is shown that a portion of the large extracellular domain determines sensitivity toward BZ ligands with sedative as well as anxiolytic activities and a single histidine residue in the alpha 1 variant, replaced by an arginine in alpha 6, as a major determinant for high affinity binding of BZ agonists.
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The neuropharmacological and neurochemical basis of place learning in the Morris water maze
TL;DR: The Morris water maze offers several advantages over other methods of studying the neurochemical basis of learning and memory, particularly with respect to its ability to dissociate deficits in memory formation from deficits in sensory, motor, motivational and retrieval processes.
References
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Book
Ionic channels of excitable membranes
TL;DR: The Ionic Channel of Excitable Membranes (ICOMB) as discussed by the authors is an extended version of ICOMB with new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology.
Journal Article
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
TL;DR: It has been shown that buprenorphine is a partial agonist of the mu type which both suppressed and precipitated abstinence in the morphine-dependent dog while morphine and propoxyphene are stronger agonists.
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Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.
Related Papers (5)
3 H-baclofen and 3 H-GABA bind to bicuculline-insensitive GABA B sites in rat brain
D. R. Hill,N. G. Bowery +1 more