Gabapentin: a multimodal perioperative drug?
V.K.F Kong,Michael G. Irwin +1 more
TLDR
Clinical trial data are reviewed describing the efficacy and safety of gabapentin in the setting of perioperative anaesthetic management for chronic post-surgical pain, postoperative nausea and vomiting, and delirium.Abstract:
Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain. It was not, until recently, thought to be useful in acute perioperative conditions. However, a growing body of evidence suggests that perioperative administration is efficacious for postoperative analgesia, preoperative anxiolysis, attenuation of the haemodynamic response to laryngoscopy and intubation, and preventing chronic post-surgical pain, postoperative nausea and vomiting, and delirium. This article reviews the clinical trial data describing the efficacy and safety of gabapentin in the setting of perioperative anaesthetic management.read more
Citations
More filters
Journal ArticleDOI
International guidelines for groin hernia management
Maarten Simons,M. Smietanski,Hendrik J. Bonjer,Reinhard Bittner,Marc Miserez,Th. J. Aufenacker,Robert J. Fitzgibbons,Pradeep Chowbey,H. M. Tran,R. Sani,Frederik Berrevoet,Juliane Bingener,Thue Bisgaard,Kamil Bury,Giampiero Campanelli,David C. Chen,Joachim Conze,Diego Cuccurullo,A. C. de Beaux,Hasan H. Eker,René H. Fortelny,J. F. Gillion,B. van den Heuvel,William W. Hope,Lars N. Jorgensen,Uwe Klinge,Ferdinand Köckerling,J. Kukleta,I. Konate,A. L. Liem,Davide Lomanto,M. J. A. Loos,Manuel López-Cano,Mahesh C. Misra,Agneta Montgomery,Salvador Morales-Conde,F. Muysoms,H Niebuhr,Pär Nordin,Maciej Pawlak,G. H. van Ramshorst,Wolfgang Reinpold,D. L. Sanders,N. Schouten,S. Smedberg,R. K. J. Simmermacher,Sathien Tumtavitikul,N. van Veenendaal,Dirk Weyhe,A. R. Wijsmuller +49 more
TL;DR: The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair.
Journal ArticleDOI
Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS)
Timothy J.P. Batchelor,Neil J. Rasburn,Etienne Abdelnour-Berchtold,Alessandro Brunelli,Robert J. Cerfolio,Michel Gonzalez,Olle Ljungqvist,René Horsleben Petersen,Wanda M. Popescu,Peter Slinger,Babu Naidu +10 more
TL;DR: This review aims to present consensus recommendations for the optimal perioperative management of patients undergoing thoracic surgery (principally lung resection) using meta-analyses, randomized controlled trials, large non-randomized studies and reviews.
Journal ArticleDOI
Multimodal therapies for postoperative nausea and vomiting, and pain
A. Chandrakantan,P.S.A. Glass +1 more
TL;DR: A multimodal approach to PONV should not be limited to drug therapy alone but should involve a holistic approach starting before operation and continuing intraoperatively with risk reduction strategies to which are added prophylactic antiemetics according to the assessed patient risk.
Journal ArticleDOI
Perioperative Use of Gabapentinoids for the Management of Postoperative Acute Pain.
Michael Verret,François Lauzier,Ryan Zarychanski,Caroline Perron,Xavier Savard,Anne-Marie Pinard,Guillaume Leblanc,Marie-Joëlle Cossi,Xavier Neveu,Alexis F. Turgeon +9 more
TL;DR: The routine use of pregabalin or gabapentin for the management of postoperative pain in adult patients is not supported, as no clinically significant analgesic effect for the perioperative use of gABapentinoids was observed and there was also no effect on the prevention of post operative chronic pain and a greater risk of adverse events.
Journal ArticleDOI
Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy
TL;DR: A single preoperative oral dose of pregabalin 150 mg is an effective method for reducing postoperative pain and fentanyl consumption in patients undergoing laparoscopic cholecystectomy.
References
More filters
Journal ArticleDOI
Assessing the quality of reports of randomized clinical trials : is blinding necessary?
Alejandro R. Jadad,R. A. Moore,Dawn Carroll,C. Jenkinson,David Reynolds,David J. Gavaghan,Henry J McQuay +6 more
TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
Journal ArticleDOI
Neuronal plasticity: increasing the gain in pain.
TL;DR: Here, a conceptual framework for the contribution of plasticity in primary sensory and dorsal horn neurons to the pathogenesis of pain is developed, identifying distinct forms of Plasticity, which are term activation, modulation, and modification, that by increasing gain, elicit pain hypersensitivity.
Journal ArticleDOI
A multicomponent intervention to prevent delirium in hospitalized older patients.
Sharon K. Inouye,Sidney T. Bogardus,Peter Charpentier,Linda Leo-Summers,Denise Acampora,Theodore R. Holford,Leo M. Cooney +6 more
TL;DR: The intervention was associated with significant improvement in the degree of cognitive impairment among patients with cognitive impairment at admission and a reduction in the rate of use of sleep medications among all patients, suggesting that primary prevention of delirium is probably the most effective treatment strategy.
Journal ArticleDOI
Gabapentin for the Symptomatic Treatment of Painful Neuropathy in Patients With Diabetes Mellitus: A Randomized Controlled Trial
Miroslav Backonja,Ahmad Beydoun,Keith R. Edwards,Sherwyn Schwartz,Vivian Fonseca,Marykay Hes,L. LaMoreaux,Elizabeth A. Garofalo +7 more
TL;DR: Gabapentin monotherapy appears to be efficacious for the treatment of pain and sleep interference associated with diabetic peripheral neuropathy and exhibits positive effects on mood and quality of life.
Journal ArticleDOI
Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial.
TL;DR: Gabapentin is effective in the treatment of pain and sleep interference associated with PHN and Mood and quality of life also improve with gabapentin therapy.