Journal ArticleDOI
Gadolinium deposition in the brain: summary of evidence and recommendations
Vikas Gulani,Fernando Calamante,Fernando Calamante,Frank G. Shellock,Emanuel Kanal,Scott B. Reeder +5 more
TLDR
Recommendations for the clinical and research use of gadolinium-based contrast agents are presented and might evolve as new evidence becomes available.Abstract:
Emerging evidence has linked MRI signal changes in deep nuclei of the brain with repeated administration of gadolinium-based contrast agents. Gadolinium deposits have been confirmed in brain tissue, most notably in the dentate nuclei and globus pallidus. Although some linear contrast agents appear to cause greater MRI signal changes than some macrocyclic agents, deposition of gadolinium has also been observed with macrocyclic agents. However, the extent of gadolinium deposition varies between agents. Furthermore, the clinical significance of the retained gadolinium in the brain, if any, remains unknown. No data are available in human beings or animals to show adverse clinical effects due to the gadolinium deposition in the brain. On behalf of the International Society for Magnetic Resonance in Medicine, we present recommendations for the clinical and research use of gadolinium-based contrast agents. These recommendations might evolve as new evidence becomes available.read more
Citations
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Rare earth elements:A review of applications, occurrence, exploration, analysis, recycling, and environmental impact
TL;DR: In this article, the authors summarized the occurrence of rare earth elements in the Earth's crust, their mineralogy, different types of deposits both on land and oceans from the standpoint of the new data with more examples from the Indian subcontinent.
Journal ArticleDOI
Deep learning enables reduced gadolinium dose for contrast-enhanced brain MRI
TL;DR: There are concerns over gadolinium deposition from gadolinia‐based contrast agents (GBCA) administration.
Journal ArticleDOI
2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis
Mike P. Wattjes,Olga Ciccarelli,Olga Ciccarelli,Daniel S. Reich,Brenda Banwell,Brenda Banwell,Nicola De Stefano,Christian Enzinger,Franz Fazekas,Massimo Filippi,Jette L. Frederiksen,Claudio Gasperini,Yael Hacohen,Yael Hacohen,Ludwig Kappos,David K.B. Li,Kshitij Mankad,Xavier Montalban,Xavier Montalban,Scott D. Newsome,Jiwon Oh,Jacqueline Palace,Maria A. Rocca,Jaume Sastre-Garriga,Mar Tintoré,Anthony Traboulsee,Hugo Vrenken,Tarek A. Yousry,Tarek A. Yousry,Frederik Barkhof,Frederik Barkhof,Alex Rovira +31 more
TL;DR: In this paper, the authors proposed changes in MRI acquisition protocols, such as emphasising the value of three dimensional-fluid-attenuated inversion recovery as the core brain pulse sequence to improve diagnostic accuracy and ability to identify new lesions to monitor treatment effectiveness.
Journal ArticleDOI
Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents
TL;DR: This review aims to examine the strategic design of ligands synthesised for this purpose, provide an overview of recent successes in gadolinium-based contrast agent development and assess the requirements for clinical translation.
Journal ArticleDOI
Gadolinium Deposition in Brain: Current Scientific Evidence and Future Perspectives
TL;DR: This review summarizes the current evidence on gadolinium deposition in the human and animal bodies, evaluates the effects of different types of GBCAs on the gadolinia deposition, introduces the possible entrance or clearance mechanism of the Gadolinium and potential side effects that may be related to the gadoliniium deposition on human or animals, and puts forward some suggestions for further research.
References
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Journal ArticleDOI
Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging.
Robert J. McDonald,Jennifer S. McDonald,David F. Kallmes,Mark E. Jentoft,David L. Murray,Kent R. Thielen,Eric E. Williamson,Laurence J. Eckel +7 more
TL;DR: Intravenous GBCA exposure is associated with neuronal tissue deposition in the setting of relatively normal renal function and the generalizability to other GBCAs is investigated.
Journal ArticleDOI
High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-weighted MR Images: Relationship with Increasing Cumulative Dose of a Gadolinium-based Contrast Material
TL;DR: High SI in the dentate nucleus and globus pallidus on unenhanced T1-weighted magnetic resonance (MR) images may be a consequence of the number of previous gadolinium-based contrast material administrations.
Journal ArticleDOI
Gadolinium-based Contrast Agent Accumulates in the Brain Even in Subjects without Severe Renal Dysfunction: Evaluation of Autopsy Brain Specimens with Inductively Coupled Plasma Mass Spectroscopy
Tomonori Kanda,Toshio Fukusato,Megumi Matsuda,Keiko Toyoda,Hiroshi Oba,Jun'ichi Kotoku,Takahiro Haruyama,Kazuhiro Kitajima,Shigeru Furui +8 more
TL;DR: Even in subjects without severe renal dysfunction, GBCA administration causes gadolinium accumulation in the brain, especially in the DN and GP.
Journal ArticleDOI
Gadolinium Retention in the Dentate Nucleus and Globus Pallidus Is Dependent on the Class of Contrast Agent
Alexander Radbruch,Lukas D. Weberling,Pascal J. Kieslich,Oliver Eidel,Sina Burth,Philipp Kickingereder,Sabine Heiland,Wolfgang Wick,Heinz Peter Schlemmer,Martin Bendszus +9 more
TL;DR: This study indicates that an SI increase in the DN and GP on T1-weighted images is caused by serial application of the linear GBCA gadopentetate dimeglumine but not by the macrocyclic GBCAs gadoterate meglumines.
Journal ArticleDOI
High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration
Tomonori Kanda,Marie Osawa,Hiroshi Oba,Keiko Toyoda,Jun'ichi Kotoku,Takahiro Haruyama,Koji Takeshita,Shigeru Furui +7 more
TL;DR: Hyperintensity in the DN in the dentate nucleus on unenhanced T1-weighted MR images is associated with previous administration of linear GBCA, while thePrevious administration of macrocyclic GBCAs showed no such association.