Journal ArticleDOI
Gastroparesis in the 2020s: New Treatments, New Paradigms.
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TLDR
It is expected that the 2020 decade will witness exciting developments in the understanding and treatment of gastroparesis and future studies will be guided by biomarkers correlated with patient outcomes and therapeutic efficacy to establish new paradigms in the management of Gp.Abstract:
This review highlights recent work that will lead to near-term advances in the understanding and treatment of gastroparesis (Gp). Major current advancements in the pathophysiology of Gp, include recognition of the SIP syncytium as the pacemaking unit rather than ICC alone and that Gp may be part of a pan-enteric autoimmune and/or autonomic disorder with macrophage imbalance. The development of newer techniques to assess gastric emptying (gastric emptying breath test and wireless motility capsule) and pyloric distensibility (EndoFLIP®) are allowing clinicians better characterization of their patients. In addition to pharmaceutical compounds in the pipeline, neuromodulation and endosurgical techniques, such as G-POEM, may help address refractory Gp. We expect that the 2020 decade will witness exciting developments. Treatments targeting gastrointestinal motility, immunological dysfunction, and inflammatory mediators will be evaluated. We anticipate future studies will be guided by biomarkers correlated with patient outcomes and therapeutic efficacy to establish new paradigms in the management of Gp.read more
Citations
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Journal ArticleDOI
Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis
Priya Vijayvargiya,Sina Jameie-Oskooei,Michael Camilleri,Victor Chedid,Patricia J. Erwin,Mohammad Hassan Murad +5 more
TL;DR: A systematic review and meta-analysis of the literature from 2007 to 2017 supports an association between optimally measured delayed gastric emptying and UGI Sx.
Journal ArticleDOI
Open-label pilot study: Non-invasive vagal nerve stimulation improves symptoms and gastric emptying in patients with idiopathic gastroparesis.
Andres Gottfried-Blackmore,Emerald P. Adler,Nielsen Fernandez-Becker,John O. Clarke,Aida Habtezion,Linda Nguyen +5 more
TL;DR: This open‐label pilot study aimed to assess the benefit of non‐invasive vagal nerve stimulation in patients with mild to moderate idiopathic gastroparesis.
Idiopathic gastroparesis is associated with specific transcriptional changes in the gastric muscularis externa
B. Paul Herring,April M. Hoggatt,Anita Gupta,Sarah L. Griffith,Attila Nakeeb,Jennifer N. Choi,Muhammad Idrees,Thomas V. Nowak,David L. Morris,John M. Wo +9 more
TL;DR: In this article, the authors used quantitative analysis of mRNA expression to identify changes in mRNAs encoding proteins required for the normal motility functions of the stomach, which are associated with idiopathic gastroparesis.
Journal ArticleDOI
Nitric Oxide: From Gastric Motility to Gastric Dysmotility
TL;DR: In this article, the influence of NO on gastric motility is discussed, with particular reference to NO synthases expression and signaling pathways, and a possible role of substances which, by interfering with NO production, could prove useful in managing such motor disorders has been advanced.
Journal ArticleDOI
Gastroparesis: A Multidisciplinary Approach to Management
Stella-Maris C. Egboh,S.A. Abere +1 more
TL;DR: The exploration of the fundamental physiological processes underlying gastroparesis with the use of biomechanical materials should be given more attention by biomedical engineers to integrate innovative engineering with medicine for solving complex medical issues.
References
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Journal ArticleDOI
Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test
TL;DR: The octanoic acid breath test is a reliable noninvasive test to measure gastric emptying rate of solids and would be applicable to field testing.
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Clinical Guideline: Management of Gastroparesis
TL;DR: Current approved treatment options, including metoclopramide and gastric electrical stimulation (GES), do not adequately address clinical need and attention should be given to the development of new effective therapies for symptomatic control.
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Epidemiology of diabetes
TL;DR: The latest estimates show a global prevalence of 382 million people with diabetes in 2013, expected to rise to 592 million by 2035 and the aetiological classification of diabetes has now been widely accepted.
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Calcium Pumps in Health and Disease
Marisa Brini,Ernesto Carafoli +1 more
TL;DR: The molecular understanding of the function of the pumps has received great impetus from the solution of the three-dimensional structure of one of them, the SERCA pump, which has paralleled the rapid expansion of knowledge in the topic of Ca2+-signaling dysfunction.
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American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis
TL;DR: A literature review and the recommendations herein were prepared for the American Gastroenterological Association Clinical Practice Committee and were approved by the Committee on May 16, 2004, and by the AGA Governing Board on September 23, 2004 as mentioned in this paper.