Journal ArticleDOI
Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes.
Lawrence F. Eng,Lawrence F. Eng +1 more
TLDR
The glial fibrillary acidic protein (GFA protein or GFAP) is the major protein constituent of glial intermediate filaments in differentiated fibrous and protoplasmic astrocytes of the central nervous system.About:
This article is published in Journal of Neuroimmunology.The article was published on 1985-01-01. It has received 690 citations till now. The article focuses on the topics: GFAP stain & Glial fibrillary acidic protein.read more
Citations
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Regeneration beyond the glial scar
Jerry Silver,Jared H. Miller +1 more
TL;DR: Chondroitin and keratan sulphate proteoglycans are among the main inhibitory extracellular matrix molecules that are produced by reactive astrocytes in the glial scar, and they are believed to play a crucial part in regeneration failure.
Journal ArticleDOI
The glial nature of embryonic and adult neural stem cells
TL;DR: The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated.
Journal ArticleDOI
Glial Fibrillary Acidic Protein: GFAP-Thirty-One Years (1969–2000)
TL;DR: While the structural function of GFAP has become more acceptable, the use ofGFAP antibodies and promoters continue to be valuable in studying CNS injury, disease, and development.
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GFAP and Astrogliosis
TL;DR: This chapter summaries the various experimental models and diseases that exhibit astrogliosis and increase in glial fibrillary acidic protein (GFAP) and recent in vitro studies to inhibit GFAP synthesis are presented.
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Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
TL;DR: It is demonstrated that loss of function of RB is essential for medulloblastoma development in the mouse and strongly support the hypothesis that medullOBlastomas arise from multipotent precursor cells located in the EGL.
References
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Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence
TL;DR: The glial fibrillary acidic (GFA) protein, a brain specific protein extracted from severely gliosed human tissue, is not species specific; cross-reaction occurs between anti-human GFA protein antibodies and brain extracts of rabbit, guinea pig, rat and dog.
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An acidic protein isolated from fibrous astrocytes.
Lawrence F. Eng,Lawrence F. Eng,J.J. Vanderhaeghen,J.J. Vanderhaeghen,Amico Bignami,Amico Bignami,B. Gerstl,B. Gerstl +7 more
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Intermediate Filaments: A Chemically Heterogeneous, Developmentally Regulated Class of Proteins
TL;DR: Descmin Filaments: Integration oj Myojibrils at the Z Disc explores the role of keratin Filaments in the integration of proteins and their role in wound healing.
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All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody
TL;DR: It is suggested that all vertebrate and invertebrate intermediate filament proteins share a common antigenic determinant and the possibility that all intermediate filaments contain a 66,000 molecular weight protein.