Journal ArticleDOI
Gliosis in schizophrenia: A survey
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TLDR
It seems unlikely that a specific pattern of pathologically significant gliosis is present in schizophrenic brains and negative findings are of note because of previously reported structural differences in the temporal lobe in the schizophrenic group in this series.About:
This article is published in Biological Psychiatry.The article was published on 1986-09-01. It has received 150 citations till now. The article focuses on the topics: Gliosis.read more
Citations
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Journal ArticleDOI
The neuropathology of schizophrenia. A critical review of the data and their interpretation.
TL;DR: Functional imaging data indicate that the pathophysiology of schizophrenia reflects aberrant activity in, and integration of, the components of distributed circuits involving the prefrontal cortex, hippocampus and certain subcortical structures.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients
Francine M. Benes,Jennifer McSparren,Edward D. Bird,John Paul SanGiovanni,Stephen L. Vincent +4 more
TL;DR: In this article, the density of pyramidal cells, interneurons, and glial cells in each of the six layers of the anterior cingulate and prefrontal cortex was analyzed in 12 control and 18 schizophrenic subjects.
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GFAP and Astrogliosis
TL;DR: This chapter summaries the various experimental models and diseases that exhibit astrogliosis and increase in glial fibrillary acidic protein (GFAP) and recent in vitro studies to inhibit GFAP synthesis are presented.
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The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications
TL;DR: The results are together suggestive of an altered synaptic circuitry or “wiring” within the hippocampus and its extrinsic connections, especially with the prefrontal cortex, which plausibly represent the anatomical component of the aberrant functional connectivity that underlies schizophrenia.
References
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Journal ArticleDOI
Basal Ganglia and Limbic System Pathology in Schizophrenia: A Morphometric Study of Brain Volume and Shrinkage
TL;DR: The volume reductions of the limbic temporal structures and of the pallidum internum of schizophrenics are interpreted as degenerative shrinkages of unknown etiology.
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Prenatal developmental disturbances in the limbic allocortex in schizophrenics.
H. Jakob,Helmut Beckmann +1 more
TL;DR: The histological findings in the two limbic regions consisted mainly of poorly developed structure in the upper layers, with a heterotopic displacement of single groups of nerve cells in the entorhinal region, which suggests a disturbance of neuronal migration in a later phase of cortical development.
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Postmortem Evidence of Structural Brain Changes in Schizophrenia: Differences in Brain Weight, Temporal Horn Area, and Parahippocampal Gyrus Compared With Affective Disorder
Rosemary Brown,Nigel Colter,J. A. Nicholas Corsellis,Timothy J. Crow,Christopher Frith,Roger Jagoe,Eve C. Johnstone +6 more
TL;DR: The findings provide postmortem confirmation of reports of ventricular enlargement in radiological studies and suggest that such enlargement is associated with tissue loss in the temporal lobe.
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Neuropathology of schizophrenia.
TL;DR: Although few differences were apparent in material from schizophrenic and nonpsychiatric cases in sections stained for cellular structures, myelin, or axis cylinders, Holzer's stain for glial fibrils demonstrated increased flbrillary gliosis that affected principally the periventricular structures of the diencephalon, the periaqueductal region of the mesencephalons, or the basal forebrain in three fourths of the brains from schizophreniaic subjects.
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Observations on the astrocyte response to a cerebral stab wound in adult rats
TL;DR: It is proposed that astrocytes respond primarily to the mechanical disruption consequent to injury and that the response promotes the restoration of the structural integrity of the lesioned tissue.
Related Papers (5)
Prenatal developmental disturbances in the limbic allocortex in schizophrenics.
H. Jakob,Helmut Beckmann +1 more