Journal ArticleDOI
Glutamate and related amino acids in cat spinal roots, dorsal root ganglia and peripheral nerves.
A.W. Duggan,Graham A.R. Johnston +1 more
TLDR
The unique regional distribution of glutamate is consistent with the proposed role of this amino acid as an excitatory transmitter at the terminals of primary afferent fibres.Citations
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Uptake of (3H)glycine and (14C)glutamate by cultures of chick spinal cord.
TL;DR: Spinal cord explants from chick embryos, grown in culture for up to 16 days, rapidly accumulated [3H]glycine and [14C]glutamate when incubated at 25° C in a medium containing either 2 × 10−10 M glycine or 4·8 ×10−8 M glutamate.
Journal ArticleDOI
An analysis of the compartmentation and proximo-distal convection of the glutamate-glutamine system in the dorsal sensory neuron: Comparison with the motoneuron and cerebral cortex
TL;DR: It would appear that as the free glutamate content decreases in passing from cerebral cortex to ventral spinal grey to dorsal root ganglion, so also does the size difference of the two glutamate-tricar☐ylic acid cycle compartments also decrease.
Journal ArticleDOI
Intradermal injection of capsaicin induces acute substance P release from rat spinal cord dorsal horn.
TL;DR: This study has provided direct evidence of the effect of intradermal injection of capsaicin on SP release within the dorsal horn, with the major source being from the central terminals of primary afferents.
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L1 and GAD65 are expressed on dorsal commissural axons in embryonic rat spinal cord.
TL;DR: Using immunocytochemical methods, the cell adhesion molecule L1 was detected on axons crossing in the dorsal commissure of developing rat spinal cord, adding to the growing evidence that this molecule may play a role in axon outgrowth and fasciculation.
References
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Journal ArticleDOI
Automatic recording apparatus for use in the chromatography of amino acids.
Journal ArticleDOI
The excitation and depression of spinal neurones by structurally related amino acids.
David R. Curtis,J. C. Watkins +1 more
TL;DR: A survey of the activity of compounds structurally related to both series of amino acids finds that one of them or a related substance may have excitatory transmitter function within the nervous system.
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Ion Exchange Chromatography of Amino Acids. A Single Column, High Resolving, Fully Automatic Procedure.
Journal ArticleDOI
Distribution of some synaptic transmitter suspects in cat spinal cord: glutamic acid, aspartic acid, gamma-aminobutyric acid, glycine and glutamine.
TL;DR: Data is presented on the distribution of glutamate, glutamine, GABA, aspartate, and glycine in dorsal and ventral roots and four spinal cord areas in the cat and the relative merits of these compounds as possible spinal excitatory or inhibitory transmitters are discussed.
Journal ArticleDOI
Properties of dorsal root unmedullated fibers on the two sides of the ganglion.
TL;DR: The argument is strongly in favor of the conclusion that among d.r.C fibers, as in other fibers, there is no cross-excitation between the axons, and the view is confirmed that the velocities of conduction in the fibers can be precisely accounted for by multiplying the diameters by a constant.