Journal ArticleDOI
Glutamate and related amino acids in cat spinal roots, dorsal root ganglia and peripheral nerves.
A.W. Duggan,Graham A.R. Johnston +1 more
TLDR
The unique regional distribution of glutamate is consistent with the proposed role of this amino acid as an excitatory transmitter at the terminals of primary afferent fibres.Citations
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Journal ArticleDOI
The action of two inhibitors of glutamic acid uptake upon amino acid-induced and synaptic excitations of thalamic neurones
Scott Haldeman,H. McLennan +1 more
TL;DR: Two inhibitors of glutamate uptake, glutamic acid dimethylester (GDME) andp-chloromercuriphenylsulphonate (pCMS) have been compared and it appeared that GDME acts as a competitive while pCMS is a non-competitive antagonist of this process.
Book ChapterDOI
Amino Acid Receptors in CNS. I. GABA and Glycine in Spinal Cord
TL;DR: In some of the earliest studies it was found that a topical application of GABA to the exposed spinal cord did not reduce spinal monosynaptic reflexes even though effects were observed with factor I, but it was later found by other workers that higher concentrations were effective.
Journal ArticleDOI
Treatment options for refractory pain The role of intrathecal therapy
TL;DR: Although determining the efficacy of long-term intraspinal drug therapy has been challenging, several classes of agents have been identified to provide benefits in patients with a variety of pain types.
Functional Organization of Dorsal Horn Interneurons
TL;DR: The interactions between primary afferent fibers and spinal interneurons will be discussed, and the organization of the ascending tracts will be considered.
Book ChapterDOI
Substance P and Sensory Transmitter
TL;DR: Two papers that appeared in the 1930s had an important influence on later studies of sensory transmitters and they have particular relevance in the present chapter.
References
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Journal ArticleDOI
Automatic recording apparatus for use in the chromatography of amino acids.
Journal ArticleDOI
The excitation and depression of spinal neurones by structurally related amino acids.
David R. Curtis,J. C. Watkins +1 more
TL;DR: A survey of the activity of compounds structurally related to both series of amino acids finds that one of them or a related substance may have excitatory transmitter function within the nervous system.
Journal ArticleDOI
Ion Exchange Chromatography of Amino Acids. A Single Column, High Resolving, Fully Automatic Procedure.
Journal ArticleDOI
Distribution of some synaptic transmitter suspects in cat spinal cord: glutamic acid, aspartic acid, gamma-aminobutyric acid, glycine and glutamine.
TL;DR: Data is presented on the distribution of glutamate, glutamine, GABA, aspartate, and glycine in dorsal and ventral roots and four spinal cord areas in the cat and the relative merits of these compounds as possible spinal excitatory or inhibitory transmitters are discussed.
Journal ArticleDOI
Properties of dorsal root unmedullated fibers on the two sides of the ganglion.
TL;DR: The argument is strongly in favor of the conclusion that among d.r.C fibers, as in other fibers, there is no cross-excitation between the axons, and the view is confirmed that the velocities of conduction in the fibers can be precisely accounted for by multiplying the diameters by a constant.