Journal ArticleDOI
Glycosylated Hemoglobin in Normal Subjects and Subjects with Maturity-onset Diabetes Evidence for a Saturable System in Man
TLDR
A curve describing a nonenzymatic saturable model was found to fit the data of the two groups combined, suggesting the possible existence of a saturable system for glycosylation in man.Abstract:
Concentrations of glycosylated hemoglobin (GHb) are elevated in diabetes mellitus and are believed to reflect previous metabolic control. To better define possible determinants of GHb in man, we investigated the relationship between GHb and both fasting plasma glucose (FPG) and basal insulin (IRI) in 42 normal subjects and 29 patients with maturity-onset diabetes. Concentrations of GHb in diabetic subjects (12.7 ± 3.4, x ± S.D., per cent total hemoglobin) were significantly higher than in normal subjects (8.2 ± 1.2, pread more
Citations
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Journal ArticleDOI
Differential changes of autonomic nervous system function with age in man.
Michael A. Pfeifer,Clare R. Weinberg,Daniel L. Cook,James D. Best,Andrew Reenan,Jeffrey B. Halter +5 more
TL;DR: It is concluded that autonomic nervous system function also declines with aging, but that other age-related changes such as a decline of baroreceptor sensitivity may lead to compensatory autonomics nervous system response, which could mask underlying functional defects.
Journal ArticleDOI
The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly.
TL;DR: It seems prudent to diagnose diabetes mellitus only if fasting hyperglycemia is present, and the evidence for insulin antagonism seems the strongest but the data are certainly not conclusive.
Journal ArticleDOI
Glucose Intolerance and Aging
TL;DR: The aging process per se appears to have its own deleterious effect on tissue sensitivity to insulin, which probably contributes to the insulin resistance.
Journal ArticleDOI
Once-daily basal insulin glargine versus thrice-daily prandial insulin lispro in people with type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial
TL;DR: It is concluded that insulin glargine provides a simple and effective option that is more satisfactory to patients than is lispro for early initiation of insulin therapy, since it was associated with a lower risk of hypoglycaemia, fewer injections, less blood glucose self monitoring, and greater patient satisfaction than was insulin lis pro.
Journal ArticleDOI
Therapy focused on lowering postprandial glucose, not fasting glucose, may be superior for lowering HbA1c. IOEZ Study Group.
TL;DR: Adding a second antihyperglycemic agent, regardless of its timing of action, lowers HbA1c and glucose values and supports the importance of lowering postprandial blood glucose to optimize overall glycemic control and thus improve long-term outcomes.
References
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Journal ArticleDOI
Correlation of Glucose Regulation and Hemoglobin AIc in Diabetes Mellitus
Ronald J. Koenig,Charles M. Peterson,Robert L. Jones,Christopher Saudek,Mark L. Lehrman,Anthony Cerami +5 more
TL;DR: The periodic monitoring of hemoglobin AIc levels provides a useful way of documenting the degree of control of glucose metabolism in diabetic patients and provides a means whereby the relation of carbohydrate control to the development of sequelae can be assessed.
Journal ArticleDOI
Hemoglobin components in patients with diabetes mellitus.
TL;DR: The increase in proportions of glycohemoglobin in diabetes mellitus appears to be another example of increased glycoproteins in this disorder.
Journal ArticleDOI
The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo.
TL;DR: Results indicate that Hb A1c is slowly formed during the 120-day life-span of the erythrocyte, probably by a nonenzymatic process.
Journal ArticleDOI
Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests.
J. D. Brunzell,R. P. Robertson,Roger L. Lerner,W R Hazzard,John W. Ensinck,Edwin L. Bierman,Daniel Porte +6 more
TL;DR: Evidence for an important role for the acute insulin response in the determination of glucose disappearance rates during intravenous glucose tolerance tests is support by epidemiological data indicating 115 mg/dl as an upper limit of normal for fasting plasma glucose levels and 1.0 per cent per minute for the glucose disappearance rate.