Journal ArticleDOI
H19/miR-107/HMGB1 axis sensitizes laryngeal squamous cell carcinoma to cisplatin by suppressing autophagy in vitro and in vivo.
Liwei Chen,Zhijian Xu,Jiandong Zhao,Xingyou Zhai,Jianhui Li,Yongxia Zhang,Liang Zong,Honghua Peng,Jixia Qi,Xinru Kong,Zhongju Fang,Mingbo Liu +11 more
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TLDR
An H19–miR‐107–HMGB1 axis in regulating the autophagy‐induced drug resistance in LSCC in vitro and in vivo is indicated, providing novel targets for molecular‐targeted therapy and broadening the research for LSCC.About:
This article is published in Cell Biology International.The article was published on 2021-03-01. It has received 26 citations till now. The article focuses on the topics: Small hairpin RNA & In vivo.read more
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The role of miRNAs in ovarian cancer pathogenesis and therapeutic resistance - A focus on signaling pathways interplay.
Ahmed Ismail,Ahmed I. Abulsoud,Doaa Fathi,Ahmed Elshafei,Hesham A. El-Mahdy,Elsayed G.E. Elsakka,Ahmed Aglan,Samy Y. Elkhawaga,Ahmed S. Doghish +8 more
TL;DR: In this paper , the authors explore the function of miRNAs in the pathophysiology of ovarian cancer, their use as biomarkers, future implications, and the direction of future research.
Journal ArticleDOI
Non-coding RNA in cancer drug resistance: Underlying mechanisms and clinical applications
Xu Zhou,Xiang Ao,Zhaojun Jia,Yiwen Li,Shouxiang Kuang,C. Du,Jin-yu Zhang,Jianxun Wang,Ying Liu +8 more
TL;DR: The recent findings on the emerging role and underlying mechanisms of ncRNAs involved in cancer drug resistance are summarized and their clinical applications as biomarkers and therapeutic targets in cancer treatment are focused on.
Journal ArticleDOI
Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability.
TL;DR: Long non-coding RNAs (lncRNAs) are defined as a class of transcripts longer than 200 nucleotides that lack translational activities and are highly abundant across the human genome as mentioned in this paper .
Journal ArticleDOI
The role of miRNAs in laryngeal cancer pathogenesis and therapeutic resistance - A focus on signaling pathways interplay.
Maghawry Hegazy,Mohamed Amr Elkady,Amr M. Yehia,Elsayed G.E. Elsakka,Ahmed I. Abulsoud,Nourhan M. Abdelmaksoud,Ahmed Mohammed Medhat Elshafei,Tamer M. Abdelghany,Samy Y. Elkhawaga,Ahmed Ismail,Mahmoud Mokhtar,Hesham A. El-Mahdy,Ahmed S. Doghish +12 more
TL;DR: In this paper , a comprehensive and updated overview highlighting the microRNAs biogenesis, general biological functions, regulatory mechanisms, and signaling dysfunction in Laryngeal cancer carcinogenesis, in addition, their clinical potential for LC diagnosis, prognosis, and chemotherapeutics response implications.
Journal ArticleDOI
Non-coding RNA-mediated autophagy in cancer: A protumor or antitumor factor?
TL;DR: In this paper, the regulatory effects of lncRNAs and circRNAs on autophagy in the contexts of cancer initiation, progression, and resistance to chemo- or radiotherapy and provide a novel insight into cancer therapy.
References
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Journal ArticleDOI
The landscape of long noncoding RNAs in the human transcriptome
Matthew K. Iyer,Yashar S. Niknafs,Rohit Malik,Udit Singhal,Anirban Sahu,Yasuyuki Hosono,Terrence R. Barrette,John R. Prensner,Joseph R. Evans,Shuang G. Zhao,Anton Poliakov,Xuhong Cao,Saravana M. Dhanasekaran,Yi-Mi Wu,Dan R. Robinson,David G. Beer,Felix Y. Feng,Hariharan K. Iyer,Arul M. Chinnaiyan +18 more
TL;DR: The lncRNA landscape characterized here may shed light on normal biology and cancer pathogenesis and may be valuable for future biomarker development.
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Long Noncoding RNA and Cancer: A New Paradigm.
TL;DR: The emerging functions and association of lncRNAs in different types of cancer and their potential implications in cancer diagnosis and therapy are reviewed.
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The H19 non-coding RNA is essential for human tumor growth.
Imad Matouk,Nathan de-Groot,Shaul Mezan,Suhail Ayesh,Rasha Abu-lail,Abraham Hochberg,Eithan Galun +6 more
TL;DR: H19 RNA harbors pro-tumorigenic properties, thus the H19 gene behaves as an oncogene and may serve as a potential new target for anti-Tumor therapy.
Journal ArticleDOI
Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer
TL;DR: The results suggest that the effect of H19 in GC is mediated by the direct upregulation of ISM1 and the indirect suppression of CALN1 expression via miR-675.
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Autophagy and cancer therapy.
Yasuko Kondo,Seiji Kondo +1 more
TL;DR: Autophagy is a dynamic process of protein degradation which is typically observed during nutrient deprivation, and this type of non-apoptotic cell death has been documented mainly by observing morphological changes, so autophagic cell death is considered programmed cell death type II, whereas apoptosis is programmed cellDeath type I.