Journal ArticleDOI
Haloacetylated enol ethers 10. Condensation of β-alkoxyvinyl trifluoromethyl ketones with thiosemicarbazide. Synthesis of new trifluoromethyl 4,5-dihydro-1H-1-pyrazolethiocarboxyamides
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TLDR
In this paper, the synthesis of 3-aryl[alkyl]-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1-pyrazolethiocarboxyamides (2a−g) from the direct cyclocondensation reaction of b-alkoxyvinyl trifluorsyl ketones with thiosemicarbazide in methanol, under mild conditions, is reported.About:
This article is published in Journal of Fluorine Chemistry.The article was published on 1998-10-05. It has received 49 citations till now. The article focuses on the topics: Trifluoromethyl & Alkyl.read more
Citations
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Journal ArticleDOI
Recent advances in the chemistry of α,β-unsaturated trifluoromethylketones
Journal ArticleDOI
Recent Advances in the Synthesis of Pyrazoles. A Review
TL;DR: A five-membered, two-nitrogen-containing heterocycle ring is widely found as the core structure in a large variety of compounds that possess important agrochemical and pharmacological properties as mentioned in this paper.
Journal ArticleDOI
Trifluoroacetylation of unsymmetrical ketone acetals. A convenient route to obtain alkyl side chain trifluoromethylated heterocycles
Helio G. Bonacorso,Marcos A. P. Martins,Sandra R. T. Bittencourt,Rogerio V. Lourega,Nilo Zanatta,Alex F. C. Flores +5 more
TL;DR: In this paper, a method to obtain β-alkyl-β-methoxyvinyl trifluoromethyl ketones from the regiospecific acylation of kinetic enol ether generated in situ is reported.
Journal ArticleDOI
“Reported, but Still Unknown.” A Closer Look into 3,4-Bis- and 3,4,5-Tris(trifluoromethyl)pyrazoles
I. I. Gerus,Roman X. Mironetz,Ivan S. Kondratov,Andrei V. Bezdudny,Andrei V. Bezdudny,Yurii V. Dmytriv,Yurii V. Dmytriv,Oleg V. Shishkin,Viktoriia S. Starova,Olga A. Zaporozhets,Andrey A. Tolmachev,Andrey A. Tolmachev,Pavel K. Mykhailiuk,Pavel K. Mykhailiuk +13 more
TL;DR: The elaborated synthetic protocols allow gram-scale preparation of the target products and the obtained compounds are comprehensively characterized by means of crystallographic analysis, determination of pK(a) values and fluorescence measurements.
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Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and β-enamino trihalomethyl ketones in water
Marcos A. P. Martins,Claudio M. P. Pereira,Wilson Cunico,Sidnei Moura,Fernanda A. Rosa,Rodrigo L. Peres,Pablo Machado,Nilo Zanatta,Helio G. Bonacorso +8 more
TL;DR: A convenient method for the preparation of 5-hydroxy-5-trihalo-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones from the reaction of 1,1,1-triHalo- 4-alkoxy-3-alken-2-ones with hydroxylamine and anilines using water as solvent and under ultrasound irradiation is reported.
References
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Book
Comprehensive Heterocyclic Chemistry II
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
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Trihaloacetylated Enol Ethers - General Synthetic Procedure and Heterocyclic Ring Closure Reactions with Hydroxylamine
TL;DR: In this paper, an improved procedure was described for preparing β-trichloro- and βtrifluoroacetyl derivatives of six simple enol ethers, in analytically pure form, high yield, and on an up to molar scale.
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Synthesis and Structure−Activity Relationship of a New Series of Potent AT1 Selective Angiotensin II Receptor Antagonists: 5-(Biphenyl-4-ylmethyl)pyrazoles
TL;DR: Compound 14n, a new series of 5-(biphenyl-4-ylmethyl)pyrazoles as potent angiotensin II antagonists, shows high potency both in vitro and in vivo and is selection for clinical evaluation as an antihypertensive agent.
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Haloacetylated enol ethers. 2. Synthesis of 5-trifluoromethylpyrazoles†
TL;DR: In this paper, a pyrazole ring with a 5-trifluoromethyl substituent was constructed by reaction of 4-alkoxy-1,1, 1, 1-trifi-oro-3-alken-2-ones (1) and hydrazine, methylhydrazine and phenylhydrazines (2) in good yields.
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Haloacetylated enol ethers: 4 [6]. Synthesis of 4‐trihalomethyl‐2‐methylthiopyrimidines
TL;DR: In this paper, the synthesis of a series of 5-and 6-substituted 4-trihalomethyl-2-methylthiopyrimidines, prepared from the cyclocondensation reaction of β-alkoxyvinyl tri[fluoro]chloromethsyl ketones with 2-methyl 2-thiopseudourea sulfate, is reported.