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Handbook of Solubility Data for Pharmaceuticals
TLDR
The literature on solubility data for pharmaceuticals has changed in recent years from being mainly concerned with liquid chromatography to gas chromatography and now also includes “solid-phase” data.Abstract:
Handbook of solubility data for pharmaceuticals , Handbook of solubility data for pharmaceuticals , کتابخانه دیجیتال جندی شاپور اهوازread more
Citations
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Mathematical derivation of the Jouyban-Acree model to represent solute solubility data in mixed solvents at various temperatures
TL;DR: The combined nearly ideal binary solvent/Redlich-Kister model and its extended version, i.e. the Jouyban-Acree model, are the most common models in the solubility prediction area as mentioned in this paper.
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Solubility of Carvedilol in Ethanol + Propylene Glycol Mixtures at Various Temperatures
Sahel Vahdati,Ali Shayanfar,Jalal Hanaee,Jalal Hanaee,Fleming Martínez,William E. Acree,Abolghasem Jouyban +6 more
TL;DR: In this paper, the solubility of carvedilol in ethanol and propylene glycol mixtures at various temperatures was investigated and the results showed that carvedilols are solubile in both types of mixtures.
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Ionic liquids as a potential tool for drug delivery systems
TL;DR: The efforts made in using ILs in drug solubility, API formulation and drug delivery, including topical, transdermal and oral delivery, are presented, with particular emphasis on recent developments.
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Thermodynamic analysis of the solubility of ketoprofen in some propylene glycol + water cosolvent mixtures
TL;DR: In this article, the van't Hoff and Gibbs equations were used to evaluate the solubility of ketoprofen in propylene glycol+water (PG+W) cosolvent mixtures.
References
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
TL;DR: Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described in this article, where the rule of 5 is used to predict poor absorption or permeability when there are more than 5 H-bond donors, 10 Hbond acceptors, and the calculated Log P (CLogP) is greater than 5 (or MlogP > 415).
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A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
TL;DR: A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinal permeability are the fundamental parameters controlling rate and extent of drug absorption.
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Group‐contribution estimation of activity coefficients in nonideal liquid mixtures
TL;DR: In this article, a group-contribution method is presented for the prediction of activity coefficients in nonelectrolyte liquid mixtures, which combines the solution-of-functional-groups concept with a model for activity coefficients based on an extension of the quasi chemical theory of liquid mixture (UNIQUAC).
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Cyclodextrins as pharmaceutical solubilizers.
TL;DR: This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug Solubilization bycyclodextrins.