Journal ArticleDOI
Hepatic lipase: new insights from genetic and metabolic studies.
TLDR
Hepatic lipase catalyses the hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins as discussed by the authors, and genetic deficiency of this enzyme is associated with a unique plasma lipoprotein profile, characterized by hypertriglyceridemia and elevated concentrations of intermediate density lipoproAbstract:
Hepatic lipase catalyses the hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins. Genetic deficiency of this enzyme is associated with a unique plasma lipoprotein profile, characterized by hypertriglyceridemia and elevated concentrations of intermediate density lipoproread more
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Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease
B.G. Brown,Xue-Qiao Zhao,Alan Chait,L D Fisher,M.C. Cheung,Josh S. Morse,Alice Dowdy,Emily K Marino,Bolson El,Petar Alaupovic,Jiri J. Frohlich,John J. Albers +11 more
TL;DR: Simvastatin plus niacin provides marked clinical and angiographically measurable benefits in patients with coronary disease and low HDL levels, and the use of antioxidant vitamins in this setting must be questioned.
Genetic Dissection of Complex Traits
TL;DR: The current state of the genetic dissection of complex traits is summarized in this paper, which describes the methods, limitations, and recent applications to biological problems, including linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses.
Journal ArticleDOI
High Density Lipoproteins and Arteriosclerosis: Role of Cholesterol Efflux and Reverse Cholesterol Transport
TL;DR: High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease, and HDL exerts various potentially antiatherogenic properties, including the mediation of reverse transport of cholesterol from cells of the arterial wall to the liver and steroidogenic organs.
Journal ArticleDOI
Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis
Anatol Kontush,M. John Chapman +1 more
TL;DR: A preferential increase in circulating concentrations of HDL particles possessing normalized antiatherogenic activity is therefore a promising therapeutic strategy for the treatment of common metabolic diseases featuring dyslipidemia, inflammation, and premature atherosclerosis.
Journal ArticleDOI
Nuclear Magnetic Resonance Spectroscopy of Lipoproteins and Risk of Coronary Heart Disease in the Cardiovascular Health Study
Lewis H. Kuller,Alice M. Arnold,Russell P. Tracy,James D. Otvos,Greg L. Burke,Bruce M. Psaty,David S. Siscovick,David S. Freedman,Richard A. Kronmal +8 more
TL;DR: Small LDL, the size of LDL particles, and the greater number of HDL particles are related to incident coronary heart disease among older women.
References
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Journal ArticleDOI
Genetic dissection of complex traits
TL;DR: This article synthesizes the current state of the genetic dissection of complex traits--describing the methods, limitations, and recent applications to biological problems.
Genetic Dissection of Complex Traits
TL;DR: The current state of the genetic dissection of complex traits is summarized in this paper, which describes the methods, limitations, and recent applications to biological problems, including linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses.
Journal ArticleDOI
The investigation of linkage between a quantitative trait and a marker locus
J. K. Haseman,Robert C. Elston +1 more
TL;DR: Procedures are given, using sib pairs, for estimating linkage between a knownm-allele locus and a hypothesized two-alleel locus that governs a quantitative trait.
Journal ArticleDOI
Tracking of serum lipids and lipoproteins from childhood to adulthood. The Bogalusa Heart Study.
TL;DR: That serum lipid and lipoprotein levels continue to track from childhood into young adulthood points to the necessity of measurement early in life and, where indicated, the introduction of preventive and interventional programs aimed at developing healthy lifestyles.
Journal ArticleDOI
Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease.
P H Groot,W. A. H. J. Van Stiphout,X.H. Krauss,Hans Jansen,A. van Tol,E. van Ramshorst,S Chin-On,Albert Hofman,S R Cresswell,Louis M. Havekes +9 more
TL;DR: The data indicate that the clearance of postprandial lipoproteins in normolipidemic CAD patients as selected in the present study is delayed as compared with that of controls without coronary atherosclerosis and suggest that postpr andial lipiproteins may play a role in the etiology of their disease.