Journal ArticleDOI
Hepatic xanthine oxidase activity and purine nucleosides levels as physiological mediators to analyze a subcutaneous treatment with (PhSe)2 in mice infected by Toxoplasma gondii.
Pedro H. Doleski,Daniela B.R. Leal,Vanessa S. Machado,Nathieli B. Bottari,Emerson André Casali,Cesar Eduardo Jacintho Moritz,Giovana Camillo,Fernanda Silveira Flores Vogel,Lenita M. Stefani,Aleksandro S. Da Silva +9 more
TLDR
It is concluded that chronic infection caused by T. gondii can induce hepatic changes, such as increased UA levels and XO activity, that can increase the pro-oxidative profile.About:
This article is published in Microbial Pathogenesis.The article was published on 2017-03-01. It has received 12 citations till now. The article focuses on the topics: Xanthine oxidase & Xanthine.read more
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Journal ArticleDOI
The Double-Edged Sword Profile of Redox Signaling: Oxidative Events As Molecular Switches in the Balance between Cell Physiology and Cancer
Sonia Emanuele,Antonella D'Anneo,Giuseppe Calvaruso,Cesare Cernigliaro,Michela Giuliano,Marianna Lauricella +5 more
TL;DR: In this article, the authors discuss the most recent findings pertaining to reactive oxygen species (ROS) physiological roles as well as highlight the controversial involvement of ROS in tumor systems, which is known to be tumorigenic and also because tumor cells are able to modify their redox state, regulating ROS production to sustain tumor growth and proliferation.
Journal ArticleDOI
Diphenyl diselenide dietary supplementation alleviates behavior impairment and brain damage in grass carp (Ctenopharyngodon idella) exposed to methylmercury chloride.
Matheus D. Baldissera,Carine F. Souza,Aleksandro S. Da Silva,Alessandra S. Henn,Erico M.M. Flores,Bernardo Baldisserotto +5 more
TL;DR: In this article, the effects of CH3HgCl exposure in grass carp Ctenopharyngodon idella were investigated and it was shown that dietary supplementation with 3 ¼mg/kg Ph2Se2 ameliorated locomotor activity impairment and prevented the augmented brain cortisol and ROS levels as well as XO activity.
Journal ArticleDOI
Xanthine oxidase activity exerts a pro-oxidant and pro-inflammatory profile in gills of experimentally infected silver catfish with Streptococcus agalactiae
Matheus D. Baldissera,Carine F. Souza,Pedro H. Doleski,Karen L.S. Moreira,Maria Izabel U.M. da Rocha,Marcelo L. da Veiga,Roberto Christ Vianna Santos,Bernardo Baldisserotto +7 more
TL;DR: In this article, the upregulation of branchial xanthine oxidase activity may be considered a pathway involved in reactive oxygen species (ROS) and nitric oxide (NO) metabolites production in experimentally infected Rhamdia quelen (silver catfish) with Streptococcus agalactiae.
Journal ArticleDOI
A caffeine-supplemented diet modulates oxidative stress markers and prevents oxidative damage in the livers of Nile tilapia (Oreochromis niloticus) exposed to hypoxia.
Matheus D. Baldissera,Carine F. Souza,Sharine N. Descovi,Tiago Goulart Petrolli,Aleksandro S. Da Silva,Bernardo Baldisserotto +5 more
TL;DR: The use of dietary supplementation with 8% caffeine can be an interesting approach to preventing hepatic lipid damage and impairment of the antioxidant defense system elicited by hypoxia, and this effect can be mediated by protective effects on XO activity.
Journal ArticleDOI
(p-ClPhSe)2 Reduces Hepatotoxicity Induced by Monosodium Glutamate by Improving Mitochondrial Function in Rats.
Caroline B. Quines,Pietro Maria Chagas,Diane Duarte Hartmann,Nelson Rodrigues de Carvalho,Félix Alexandre Antunes Soares,Cristina W. Nogueira +5 more
TL;DR: It is demonstrated that postnatal administration of MSG to male rats induced a mitochondrial dysfunction, accompanied by oxidative stress and an increase in the ADP levels, without altering the efficiency of phosphorylation in the liver of adult rats.
References
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Book ChapterDOI
Receptors for Purines and Pyrimidines
Vera Ralevic,Geoffrey Burnstock +1 more
TL;DR: In this review particular emphasis is placed on the discrepancy between the concentrations ofadenosine, ADP, and ATP in the purine receptors of UDP and UTP.
Journal ArticleDOI
Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology
TL;DR: The development of new organochalcogens with higher thiol-peroxidase activity that can use other non-toxic thiol reducing agents, such as N-acetylcysteine instead of glutathione, will permit the investigation of the co-administration of organochAlcogens and thiols as a formulation for antioxidant therapy.
Journal ArticleDOI
Structures of Toxoplasma gondii Tachyzoites, Bradyzoites, and Sporozoites and Biology and Development of Tissue Cysts
TL;DR: A detailed account of the biology of tissue cysts and bradyzoites including in vivo and in vitro development, methods of separation from host tissue, tissue cyst rupture, and relapse is provided.
Journal ArticleDOI
Relationship Between Serum Uric Acid Concentration and Insulin Resistance and Metabolic Syndrome
Tae Woo Yoo,Ki Chul Sung,Hun Sub Shin,Byung Jin Kim,Bum Soo Kim,Jin Ho Kang,Man Ho Lee,Jung Ro Park,Hyang Kim,Eun-Jung Rhee,Won Young Lee,Sun Woo Kim,Seungho Ryu,Dong Geuk Keum +13 more
TL;DR: Serum uric acid concentration was found to be independently correlated with hypertension, insulin resistance and the risk factors of metabolic syndrome, and even those with a serum uric Acid concentration in the normal range showed an increased risk of metabolic Syndrome as serum uri acid concentration increased.
Journal ArticleDOI
Diphenyl diselenide a janus-faced molecule
Cristina W. Nogueira,João Rocha +1 more
TL;DR: The papers covered in this review indicate that a limited activation of the "toxic pathway", i.e., a controlled oxidation of specific high molecular weight thiol-containing molecules could contribute to the pharmacological effects of diphenyl diselenide.