Journal ArticleDOI
High Risk of Symptomatic Cardiac Events in Childhood Cancer Survivors
Helena J.H. van der Pal,Elvira C. van Dalen,Evelien van Delden,Irma W. E. M. van Dijk,Wouter E.M. Kok,Ronald B. Geskus,Elske Sieswerda,Foppe Oldenburger,Caro C.E. Koning,Flora E. van Leeuwen,Huib N. Caron,Leontien C. M. Kremer +11 more
TLDR
CCSs have a high risk of developing symptomatic CEs at an early age; survivors treated with both anthracyclines and radiotherapy have the highest risk; after 30 years, one in eight will develop severe heart disease.Abstract:
Purpose To evaluate the long-term risk for validated symptomatic cardiac events (CEs) and associated risk factors in childhood cancer survivors (CCSs). Patients and Methods We determined CEs grade 3 or higher: congestive heart failure (CHF), cardiac ischemia, valvular disease, arrhythmia and/or pericarditis (according to Common Terminology Criteria for Adverse Events [CTCAE], version 3.0) in a hospital-based cohort of 1,362 5-year CCSs diagnosed between 1966 and 1996. We calculated both marginal and cause-specific cumulative incidence of CEs and cause-specific cumulative incidence of separate events. We analyzed different risk factors in multivariable Cox regression models. Results Overall, 50 CEs, including 27 cases of CHF, were observed in 42 survivors (at a median attained age of 27.1 years). The 30-year cause-specific cumulative incidence of CEs was significantly increased after treatment with both anthracyclines and cardiac irradiation (12.6%; 95% CI, 4.3% to 20.3%), after anthracyclines (7.3%; 95% C...read more
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European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012)
Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Y.M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W M Monique Verschuren +25 more
TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
Journal ArticleDOI
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja-Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Yvo M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W. M. Monique Verschuren +25 more
TL;DR: ABI is ankle-brachial (blood pressure) index and ABPM is ambulatory blood pressure monitoring as mentioned in this paper ; ACCORD is action to control cardiovascular risk in Diabetes and Vascular disease.
Journal ArticleDOI
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Massimo F Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Christi Deaton,Christi Deaton,Ian D. Graham,Michael Stephen Hall,Michael Stephen Hall,FD Richard Hobbs,Maja Lisa Løchen,Maja Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Yvo M. Smulders,Monica Tiberi,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W. M. Monique Verschuren,Simone Binno +32 more
TL;DR: Authors/Task Force Members: Massimo F. Piepoli (Chairperson), Arno W. Hoes (Co-Chairperson) (The Netherlands), Stefan Agewall (Norway) 1, Christian Albus (Germany)9, Carlos Brotons (Spain)10, Alberico L. Catapano (Italy)3, Marie-Therese Cooney (Ireland)1, Ugo Corrà (Italy).
Journal ArticleDOI
2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR).
Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie-Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,F. D. Richard Hobbs,Maja-Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Y.M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W M Monique Verschuren,Additional Contributor: Simone Binno,Guy De Backer,Marco Roffi,Victor Aboyans,Norbert Bachl,Héctor Bueno,Scipione Carerj,Leslie Cho,John Cox,Johan De Sutter,Günther Egidi,Miles Fisher,Donna Fitzsimons,Oscar H. Franco,Maxime Guenoun,Catriona Jennings,Borut Jug,Paulus Kirchhof,Kornelia Kotseva,Gregory Y.H. Lip,François Mach,Giuseppe Mancia,Franz Martin Bermudo,Alessandro Mezzani,Alexander Niessner,Piotr Ponikowski,Bernhard Rauch,Lars Rydén,Adrienne Stauder,Guillaume Turc,Olov Wiklund,Stephan Windecker,José Luis Zamorano +58 more
Journal ArticleDOI
Survivors of childhood and adolescent cancer: life-long risks and responsibilities
TL;DR: The burden of responsibility to understand the long-term morbidity and mortality that is associated with currently successful treatments must be borne by many, including the research and health care communities, survivor advocacy groups, and governmental and policy-making entities.
References
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Journal ArticleDOI
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Journal ArticleDOI
Late Cardiac Effects of Doxorubicin Therapy for Acute Lymphoblastic Leukemia in Childhood
Steven E. Lipshultz,Steven D. Colan,Richard D. Gelber,Antonio R. Perez-Atayde,Stephen E. Sallan,Stephen P. Sanders +5 more
TL;DR: Doxorubicin therapy in childhood impairs myocardial growth in a dose-related fashion and results in a progressive increase in left ventricular afterload sometimes accompanied by reduced contractility, hypothesized to result in inadequateleft ventricular mass and clinically important heart disease in later years.