Journal ArticleDOI
Higher Risk of Preterm Birth and Low Birth Weight in Women with Periodontal Disease
TLDR
PD was associated with both preterm birth and low birth weight, independent of other risk factors, and risk factors significantly associated with PLBW were previous PLBW, PD, fewer than 6 prenatal visits, and low maternal weight gain.Abstract:
Pregnant women with periodontal disease (PD) may be at increased risk for having preterm low-birth-weight (PLBW) children. We investigated whether the maintenance of the mothers' periodontal health after 28 weeks' gestation reduces the risk of PLBW. Of the 639 women studied, 406 had gingivitis and received treatment before 28 weeks' gestation, and 233 had PD and were treated after delivery. Data about previous and current pregnancies and known risk factors were obtained from patients' medical records. Primary outcomes were delivery before 37 weeks' gestation or an infant with birth weight below 2500 g. The incidence of PLBW was 2.5% in periodontally healthy women, and 8.6% in women with PD (p = 0.0004, relative risk = 3.5, 95% CI, 1.7 to 7.3). Risk factors significantly associated with PLBW were previous PLBW, PD, fewer than 6 pre-natal visits, and low maternal weight gain. PD was associated with both preterm birth and low birth weight, independent of other risk factors.read more
Citations
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Journal ArticleDOI
Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease: A randomized controlled trial
TL;DR: periodontal disease appears to be an independent risk factor for preterm low birth weight (PLBW) in this population of women with periodontal Disease.
Journal ArticleDOI
Periodontal disease and adverse pregnancy outcomes: a systematic review
TL;DR: This work has shown that periodontal disease, as a source of subclinical and persistent infection, may induce systemic inflammatory responses that increase the risk of adverse pregnancy outcomes.
Journal ArticleDOI
Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue.
TL;DR: It is confirmed that LPS from periodontal bacteria can access the AD brain during life as labeling in the corresponding controls, with equivalent/longer postmortem interval, was absent.
Journal ArticleDOI
Progressive periodontal disease and risk of very preterm delivery.
Steven Offenbacher,Kim A. Boggess,Amy P. Murtha,Heather Jared,Susan Lieff,Rosemary G. McKaig,Sally M. Mauriello,Kevin Moss,James D. Beck +8 more
TL;DR: It is demonstrated that maternal periodontal disease increases relative risk for preterm or spontaneous preterm births and was a predictor of the more severe adverse pregnancy outcome of very preterm birth, independently of traditional obstetric,periodontal, and social domain risk factors.
Journal ArticleDOI
Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease
Pamela S. Stein,M. J. Steffen,Charles D. Smith,Gregory A. Jicha,Jeffrey L. Ebersole,Erin L. Abner,Dolph Dawson +6 more
TL;DR: In this paper, the authors examined serum antibody levels to bacteria associated with periodontal disease in participants who eventually converted to Alzheimer's disease compared with the antibody levels in control subjects.
References
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Journal Article
Determinants of low birth weight: Methodological assessment and meta-analysis
TL;DR: There is a need for future research on the effect of maternal work, prenatal care, and certain vitamin and mineral deficiencies on intrauterine growth, and theeffect of genital tract infection, prenatal Care, maternal employment, stress and anxiety on prematurity.
Journal ArticleDOI
Periodontal Infection as a Possible Risk Factor for Preterm Low Birth Weight
Steven Offenbacher,Vern Katz,Gregory Fertik,John A. Collins,Doryck Boyd,Doryck Boyd,Gayle Maynor,Rosemary G. McKaig,James D. Beck +8 more
TL;DR: It is demonstrated that periodontal disease is a statistically significant risk factor for PLBW with adjusted odds ratios of 7.9 and 7.5 for all PLBW cases and primiparous PL BW cases, respectively.
Journal ArticleDOI
Potential Pathogenic Mechanisms of Periodontitis-Associated Pregnancy Complications
Steven Offenbacher,Heather Jared,P. G. O'Reilly,S. R. Wells,Giovanni E. Salvi,Herenia P. Lawrence,Sigmund S. Socransky,James D. Beck +7 more
TL;DR: New experiments from 48 case-control subjects have measured gingival crevicular fluid (GCF) levels of PGE(2) and IL-1-beta to determine whether mediator levels were related to current pregnancy outcome, and microbes associated with mature plaque and progressing periodontitis were detected at higher levels in PLBW mothers, as compared to NBW controls.