Journal ArticleDOI
Recent developments in isocyanide based multicomponent reactions in applied chemistry
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This article is published in Chemical Reviews.The article was published on 2006-01-01. It has received 3685 citations till now. The article focuses on the topics: Isocyanide & Passerini reaction.read more
Citations
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Green Chemistry: Principles and Practice
Paul T. Anastas,Nicolas Eghbali +1 more
TL;DR: The concepts of design and the scientific philosophy of Green Chemistry are covered with a set of illustrative examples and the challenge of using the Principles as a cohesive design system is discussed.
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Chemistry and Biology Of Multicomponent Reactions
TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
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Cascade reactions in total synthesis.
TL;DR: The power of cascade reactions in total synthesis is illustrated in the construction of complex molecules and underscore their future potential in chemical synthesis.
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Natural product synthesis using multicomponent reaction strategies.
B. Barry Touré,Dennis G. Hall +1 more
TL;DR: The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry, and it laid the ground for the early days of target-oriented organic synthesis, a task deemed inconceivable by early practitioners.
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Aerobic Copper-Catalyzed Organic Reactions
TL;DR: The chemistry of copper is extremely rich because it can easily access Cu0, CuI, CuII, and CuIII oxidation states allowing it to act through one-electron or two-Electron processes, which feature confer a remarkably broad range of activities allowing copper to catalyze the oxidation and oxidative union of many substrates.
References
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Journal ArticleDOI
Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
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Asymmetric multicomponent reactions (amcrs): the new frontier
Diego J. Ramón,Miguel Yus +1 more
TL;DR: Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously and has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects.
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Maximizing Synthetic Efficiency: Multi-Component Transformations Lead the Way
TL;DR: Over the last five years, industrial and academic researchers have made the unique exploratory power of some reactions into one of the most efficient and cost-effective tools for combinatorial and parallel synthesis.
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"Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.
TL;DR: This review details developments of new, highly atom-economic MCR derived chemical methods, which enable the fast and efficient production of chemical libraries comprised of a variety of biologically relevant templates, and focuses on applications of isocyanide based MCR (IMCR) reactions.
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Recent Advances in Solution-Phase Multicomponent Methodology for the Synthesis of Heterocyclic Compounds
TL;DR: A review of solution-phase multi-component procedures for the synthesis of heterocyclic compounds can be found in this paper, where the authors give an overview of the progress made in the past decade.