Histomorphometry and bone mechanical property evolution around different implant systems at early healing stages: an experimental study in dogs

TLDR: The effect of different implant designs on osseointegration was evident especially at early stages of bone healing, and both time and implant system interaction significantly affected the bone-to-implant contact.

Abstract: Purpose Commercial implants differ at macro-, micro-, and nanolevels, which makes it difficult to distinguish their effect on osseointegration. The aim of this study was to evaluate the early integration of 5 commercially available implants (Astra OsseoSpeed, Straumann SLA, Intra-Lock Blossom Ossean, Nobel Active, and OsseoFix) by histomorphometry and nanoindentation. Materials and methods Implants were installed in the tibiae of 18 beagle dogs. Samples were retrieved at 1, 3, and 6 weeks (n = 6 for each time point) and were histologically and nanomechanically evaluated. Results The results presented that both time (P 0.80; H: P > 0.75) or implant system (E: P > 0.90; H: P > 0.85). Conclusions The effect of different implant designs on osseointegration was evident especially at early stages of bone healing.