Journal ArticleDOI
How Does Intensity-Modulated Radiotherapy Versus Conventional Two-Dimensional Radiotherapy Influence the Treatment Results in Nasopharyngeal Carcinoma Patients?
Shu Zhen Lai,Wen Fei Li,Lei Chen,Wei Luo,Yuan Yuan Chen,Li Zhi Liu,Ying Sun,Ai Hua Lin,Meng Zhong Liu,Jun Ma +9 more
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TLDR
A greater improvement of treatment results with IMRT than with 2D-CRT was demonstrated primarily by achieving a higher local tumor control rate in NPC patients, especially in the early T stage patients.Abstract:
Purpose To compare the results of intensity-modulated radiotherapy (IMRT) with those of two-dimensional conventional radiotherapy (2D-CRT) in the treatment of patients with nasopharyngeal carcinoma (NPC). Methods and Materials A retrospective review of data from 1,276 patients with biopsy-proven, nonmetastatic NPC was performed. All patients had undergone magnetic resonance imaging and were staged according to the sixth edition of the American Joint Committee on Cancer staging criteria. Radiotherapy was the primary treatment for all patients. Results Of the 1,276 patients, 512 were treated with IMRT and 764 with 2D-CRT. The 5-year actuarial local relapse-free survival (LRFS), the nodal relapse-free survival (NRFS), the distant metastasis-free survival (DMFS), and the disease-free survival (DFS) rates were 92.7%, 97.0%, 84.0%, and 75.9%, respectively, for the IMRT group, and 86.8%, 95.5%, 82.6%, and 71.4%, respectively, for the 2D-CRT group. In stage T1 patients, improvement of LRFS in the IMRT group was even significantly higher than in the 2D-CRT group (100% vs. 94.4%; p = 0.016). A trend of improvement of DFS was observed in the IMRT group compared with the 2D-CRT group but without reaching statistical significance. NRFS and DMFS rates were similar in the two groups. Conclusions A greater improvement of treatment results with IMRT than with 2D-CRT was demonstrated primarily by achieving a higher local tumor control rate in NPC patients, especially in the early T stage patients. The goal of better control of both local failure in advanced, nonmetastatic NPC patients and of distant failure should be addressed in future studies.read more
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Journal ArticleDOI
Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial
Ying Sun,Wen Fei Li,Nian Yong Chen,Ning Zhang,Guoqing Hu,Fang Yun Xie,Yan Sun,Xiao Zhong Chen,Jin Gao Li,Xiao-Dong Zhu,Chaosu Hu,Xiang Ying Xu,Yuan Yuan Chen,Wei Han Hu,Ling Guo,Hao Yuan Mo,Lei Chen,Yan Ping Mao,Rui Sun,Ping Ai,Shao Bo Liang,Guo Xian Long,Bao Min Zheng,Xing Lai Feng,Xiao Chang Gong,Ling Li,Chun Ying Shen,Jian Yu Xu,Ying Guo,Yu Ming Chen,Fan Zhang,Li Lin,Ling Long Tang,Meng Zhong Liu,Jun Ma +34 more
TL;DR: Addition of TPF induction chemotherapy to concurrent chemoradiotherapy significantly improved failure-free survival in locoregionally advanced nasopharyngeal carcinoma with acceptable toxicity.
Journal ArticleDOI
Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective
TL;DR: The key literature on the current management of nasopharyngeal carcinoma and future directions in clinical research are reviewed and appraises.
Journal ArticleDOI
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma
Yuan Zhang,Lei Chen,Guoqing Hu,Ning Zhang,Xiao-Dong Zhu,Kunyu Yang,Feng Jin,Mei Shi,Yu Pei Chen,Weihan Hu,Zhi-Bin Cheng,Si-Yang Wang,Ye Tian,Xicheng Wang,Yan Sun,Jin-Gao Li,Wen-Fei Li,Yu-Hong Li,Ling-Long Tang,Yan Ping Mao,Guan-Qun Zhou,Rui Sun,Xu Liu,Rui Guo,Guo-Xian Long,Shao-Qiang Liang,Ling Li,Jing Huang,Jin-Hua Long,Jian Zang,Qiao-Dan Liu,Li Zou,Qiong-Fei Su,Bao-Min Zheng,Yun Xiao,Ying Guo,Fei Han,Hao-Yuan Mo,Jia-Wei Lv,Xiao-Jing Du,Cheng Xu,Na Liu,Ying-Qin Li,Melvin L.K. Chua,Fang-Yun Xie,Ying Sun,Jun Ma +46 more
TL;DR: Induction chemotherapy added to chemoradiotherapy significantly improved recurrence-free survival and overall survival, as compared with chemoradaotherapy alone, among patients with locoregionally advanced nasopharyngeal carcinoma.
Journal ArticleDOI
A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma.
TL;DR: IMRT provides improved local-recurrence free survival, especially in late-stage NPC patients and is associated with a lower incidence of toxicities, as well as significantly lower radiation-induced toxicities than those in 2D-CRT group.
Journal ArticleDOI
The potential role of RNA N6-methyladenosine in Cancer progression
TL;DR: This review focuses on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors.
References
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Edward L. Kaplan,Paul Meier +1 more
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Journal ArticleDOI
Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099.
Muhyi Al-Sarraf,Michael LeBlanc,P.G. Giri,Karen K. Fu,Jay S. Cooper,T. Vuong,Arlene A. Forastiere,George L. Adams,Wael Sakr,David E. Schuller,John F. Ensley +10 more
TL;DR: It is concluded that chemoradiotherapy is superior to radiotherapy alone for patients with advanced nasopharyngeal cancers with respect to PFS and overall survival.