HTLV-1 infections
TLDR
The importance of the host's immune response in reducing the risk of these diseases, and the reasons why some HTLV-1 infected people develop serious illnesses whereas most remain healthy life long carriers of the virus, might be applicable to other persistent virus infections.Abstract:
Human T lymphotropic virus type 1 (HTLV-1) causes disabling and fatal diseases, yet there is no vaccine, no satisfactory treatment, and no means of assessing the risk of disease or prognosis in infected people. Recent research on the molecular virology and immunology of HTLV-1 shows the importance of the host's immune response in reducing the risk of these diseases, and is beginning to explain why some HTLV-1 infected people develop serious illnesses whereas most remain healthy life long carriers of the virus. These findings might be applicable to other persistent virus infections such as human immunodeficiency virus, hepatitis B, and hepatitis C.read more
Citations
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Journal ArticleDOI
Functional signatures of protective antiviral T-cell immunity in human virus infections
Alexandre Harari,Valérie Dutoit,Cristina Cellerai,Pierre-Alexandre Bart,Renaud Du Pasquier,Giuseppe Pantaleo +5 more
TL;DR: The levels of antigen load modulate the phenotypic and functional patterns of the T‐cell response within the same virus infection, and the functional characterization of virus‐specific CD4+ and CD8‐cell responses has identified signatures of protective antiviral immunity.
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Viral infections of humans: epidemiology and control
TL;DR: The third edition of this book has been completely revised and updated, and new chapters have been added on Hantanvirus by Karl Johnson, on retroviruses by William Blattner, and on hepatocellular carcinoma by Joseph Melnick as discussed by the authors.
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Genetic susceptibility for breast cancer: how many more genes to be found?
Rogier A. Oldenburg,Rogier A. Oldenburg,Hanne Meijers-Heijboer,C. J. Cornelisse,Peter Devilee +4 more
TL;DR: The different undertaken approaches used in identifying new breast cancer susceptibility genes, such as (genome-wide) linkage analysis, CGH, LOH, association studies and global gene expression analysis are discussed.
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Association of human endogenous retroviruses with multiple sclerosis and possible interactions with herpes viruses
TL;DR: The hypothesis that human endogenous retroviruses play a role in autoimmune diseases is subject to increasing attention and they have been isolated from MS samples of plasma, serum and CSF, and characterised to some extent at the nucleotide, protein/enzyme, virion and immunogenic level.
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Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8 + T cell functions during chronic viral infection
TL;DR: It is demonstrated that upon prolonged in vivo exposure to antigen, TCR-triggered Ca2+ flux, degranulation, and cytotoxicity are maintained on a cellular level, whereas cytokine production is severely impaired because of a selective defect in activation-induced NFAT nuclear translocation.
References
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Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
Bernard J. Poiesz,Francis W. Ruscetti,Adi F. Gazdar,Paul A. Bunn,John D. Minna,Robert C. Gallo +5 more
TL;DR: The number of these particle-associated proteins is consistent with the expected proteins of a retrovirus, but the sizes of some are distinct from those of most known retroviruses of the primate subgroups.
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Antibodies to human t-lymphotropic virus type-i in patients with tropical spastic paraparesis
TL;DR: Findings suggest either that HTLV-I is neurotropic or that the virus or a related one contributes to the pathogenesis of TSP.
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Htlv-i associated myelopathy, a new clinical entity
Mitsuhiro Osame,Koichiro Usuku,Shuji Izumo,Naomi Ijichi,Hiroyoko Amitani,Akihiro Igata,Makoto Matsumoto,Mitsutoshi Tara +7 more
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Adult T-cell leukemia : antigen in an ATL cell line and detection of antibodies to the antigen in human sera
Yorio Hinuma,Kinya Nagata,Masao Hanaoka,Masuyo Nakai,Tadashi Matsumoto,Ken-Ichiro Kinoshita,Shigeru Shirakawa,Isao Miyoshi +7 more
TL;DR: Antibodies against the antigen in MT-1 cells were found in all 44 patients with ATL examined and in 32 of 40 patients with malignant T-cell lymphomas (most of them had diseases similar to ATL except that leukemic cells were not found in the peripheral blood).
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Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease
TL;DR: Findings on the close association of ATLV protein and proviral DNA with ATL are direct evidence for the possible involvement of the retrovirus ATLV in leukemogenesis of human ATL.