Book ChapterDOI
Human and mouse hepatic aldehyde dehydrogenases important in the biotransformation of cyclophosphamide and the retinoids.
TLDR
The rate at which aldehyde dehydrogenase-catalyzed biotransformation occurs in various tissues can be of major importance with regard to the ultimate therapeutic efficacy of drugs and other xenobiotics that are aldeHydes or that give rise to aldehydes.Abstract:
The rate at which aldehyde dehydrogenase-catalyzed biotransformation occurs in various tissues can be of major importance with regard to the ultimate therapeutic efficacy of drugs and other xenobiotics that are aldehydes or that give rise to aldehydes (Sladek, et al., 1989). Examples of such agents are cyclophosphamide and the retinoids, retinol and beta-carotene.read more
Citations
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Journal ArticleDOI
Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact.
TL;DR: The absence of a fully functional first category aldehyde dehydrogenase results in a gross pathological phenotype in the absence of any insult, whereas the lack of a functional second category aLDNase is ordinarily of no consequence with respect to gross phenotype, but is of consequence in that regard when the organism is subjected to a relevant insult.
Journal ArticleDOI
Metabolism and Transport of Oxazaphosphorines and the Clinical Implications
TL;DR: This review highlights the metabolism and transport of these oxazaphosphorines (mainly CPA and IFO, as these two oxazphosphorine drugs are the most widely used alkylating agents) and the clinical implications.
Journal ArticleDOI
Clinical Pharmacology of Cyclophosphamide and Ifosfamide
TL;DR: The oxazaphosphorine cyclophosphamide (CPA) and ifosfamide (IFO) are two commonly used DNA- alkylating agents in cancer chemotherapy and the pharmacokinetics and pharmacodynamics of the two important agents are highlighted.
Journal ArticleDOI
The role of corneal crystallins in the cellular defense mechanisms against oxidative stress
TL;DR: The discussion of the antioxidant defenses of the cornea is extended to include these highly expressed corneal crystallins and address their specific capacities to minimize oxidative damage.
Journal ArticleDOI
De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality.
TL;DR: Alkaline elution studies showed that expression of ALDH-1 reduced the number of DNA cross-links commensurate with mafosfamide resistance, and this reduction in cross- links was fully reversed by the inhibitor.
References
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Journal ArticleDOI
Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals
TL;DR: It is concluded that a point mutation in the human ALDH2 locus produced the glutamine leads to lysine substitution and enzyme inactivation in atypical livers.
Journal ArticleDOI
Identification of mouse liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid
TL;DR: Seven aldehyde dehydrogenases found in the cytosol of mouse stomach epithelium and cornea catalyzed the oxidation of retinaldehyde to retinoic acid, a metabolite of vitamin A that promotes the differentiation of epithelial and other cells.
Journal ArticleDOI
Metabolism of retinoic acid and retinol during differentiation of F9 embryonal carcinoma cells.
John Williams,Joseph L. Napoli +1 more
TL;DR: It is shown that retinoic acid itself directs the differentiation of F9 cells and may mediate differentiation induced by retinol, which had a half-life approximately 5-fold longer than retinooic acid, attained greater cell concentrations, and was converted into retinoi acid by F 9 cells.
Journal ArticleDOI
Retinol metabolism in LLC-PK1 Cells. Characterization of retinoic acid synthesis by an established mammalian cell line.
TL;DR: It is suggested that substrate availability, relative to enzyme activity/amount, is a primary determinant of the rate of retinoic acid synthesis, identifies inhibitors of Retinol dehydrogenase, and places retinol acid synthesis into perspective with several other known pathways of retinoid metabolism.