Journal ArticleDOI
Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance.
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Associated with the oxazaphosphorine-specific acquired resistance exhibited by a human breast adenocarcinoma subline growing in monolayer culture, the MCF-7/OAP ALDH-3 was judged to be a novel class 3 aldehyde dehydrogenase.About:
This article is published in Biochemical Pharmacology.The article was published on 1993-06-22. It has received 84 citations till now. The article focuses on the topics: Aldehyde dehydrogenase & Aldophosphamide.read more
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Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.
TL;DR: What is currently known about each member of the human ALDH superfamily, composed of NAD(P)+-dependent enzymes that catalyze aldehyde oxidation, is presented including the pathophysiological significance of these enzymes.
Journal ArticleDOI
Clinical Pharmacokinetics of Cyclophosphamide
TL;DR: Variations in the balance between metabolic activation and inactivation of cyclophosphamide owing to autoinduction, dose escalation, drug-drug interactions and individual differences have been reported, suggesting possibilities for optimisation of cyclphosphamide therapy.
Journal ArticleDOI
Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application
Vindhya Koppaka,David C. Thompson,Ying Chen,Manuel Ellermann,Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Risto O. Juvonen,Dennis R. Petersen,Richard A. Deitrich,Thomas D. Hurley,Vasilis Vasiliou +10 more
TL;DR: The purpose of this review is to establish the current status of pharmacological inhibition of the ALDHs, provide a rationale for the continued development of ALDH isozyme-selective inhibitors, and identify the challenges and potential therapeutic rewards associated with the creation of such agents.
Journal ArticleDOI
Aldehyde Dehydrogenases in Cellular Responses to Oxidative/electrophilic Stress
Surendra Singh,Chad Brocker,Vindhya Koppaka,Ying Chen,Brian C. Jackson,Akiko Matsumoto,David C. Thompson,Vasilis Vasiliou +7 more
TL;DR: The ALDH superfamily represents a fundamentally important class of enzymes that contributes significantly to the management of electrophilic/oxidative stress within living systems and is associated with a variety of pathological conditions in humans.
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Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact.
TL;DR: The absence of a fully functional first category aldehyde dehydrogenase results in a gross pathological phenotype in the absence of any insult, whereas the lack of a functional second category aLDNase is ordinarily of no consequence with respect to gross phenotype, but is of consequence in that regard when the organism is subjected to a relevant insult.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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Disc electrophoresis – ii method and application to human serum proteins*
TL;DR: The technique of disc electrophoresis has been presented, including a discussion of the technical variables with special reference to the separation of protein fractions of normal human serum.