Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction
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The identification of hyperlipidemic survivors of myocardial infarction provided a unique source of probands for family studies designed to disclose the genetic origin ofhyperlipidemia in coronary heart disease.Abstract:
Plasma cholesterol and triglyceride levels were measured after an overnight fast in 500 consecutively studied 3-mo survivors of myocardial infarction. Virtually all patients under 60 yr of age (95% ascertainment) and a randomly chosen group of older survivors admitted to 13 Seattle hospitals during an 11 mo period were included. A comparison of their lipid values with those of 950 controls demonstrated that 31% had hyperlipidemia. These lipid abnormalities were most commonly found in males under 40 yr of age (60% frequency) and in females under 50 yr of age (60% frequency). Elevation in triglyceride levels with (7.8%) or without (15.6%) an associated elevation in cholesterol levels was three times more common in survivors than a high cholesterol level alone (7.6%). These results raise the possibility that hypertriglyceridemia may be as an important a risk factor for coronary atherosclerosis as hypercholesterolemia. The identification of hyperlipidemic survivors of myocardial infarction provided a unique source of probands for family studies designed to disclose the genetic origin of hyperlipidemia in coronary heart disease.read more
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References
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Journal Article
Cardiovascular survey methods
Geoffrey Rose,Henry W. Blackburn +1 more
TL;DR: Cardiovascular survey methods, Card cardiovascular survey methods , مرکز فناوری اطلاعات و اصاع رسانی, کδاوρزی
Journal ArticleDOI
Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease: The Framingham Study
TL;DR: Risk of coronary heart disease over 14 years was examined prospectively in 2,282 men and 2,845 women according to their antecedent cholesterol and lipoprotein status.
Journal ArticleDOI
Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIA
TL;DR: The combined disorder was shown to be genetically distinct from familial hypercholesterolemia and familial hypertriglyceridemia for the following reasons: the distribution pattern of cholesterol and triglyceride levels in relatives of probands was unique.
Journal ArticleDOI
ISCHÆMIC HEART-DISEASE IN RELATION TO FASTING VALUES OF PLASMA TRIGLYCERIDES AND CHOLESTEROL: Stockholm Prospective Study
LarsA. Carlson,L.E. Böttiger +1 more
TL;DR: In a nine-year follow-up of 3168 men in the Stockholm prospective study, the occurrence of new events of ischaemic heart-disease (I.H.D.) has been related to findings at the initial examination.
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Serum lipids, hypertension and coronary artery disease☆☆☆
TL;DR: High serum cholesterol concentrations or hypertension appeared to increase the risk of coronary disease in persons with high serum triglycerides, but by themselves seemed to carry little risk.