Journal ArticleDOI
Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset
Zhiwei Zheng,Chen Guo,Min Li,Liang Yang,Peng Li,Xuliang Zhang,Yiqin Liu,Xiaonan Guo,Shuxia Cao,Yiyan Dong,Chunlei Zhang,Min Chen,Jiamin Xu,Hailan Hu,Yihui Cui +14 more
TLDR
In this paper , the authors identify the lateral hypothalamus (LH) as the most physiologically relevant input to LHb under stress and find that LH-LHb synaptic potentiation is determinant in stress-induced depression.About:
This article is published in Neuron.The article was published on 2022-01-28. It has received 38 citations till now. The article focuses on the topics: Medicine & Long-term potentiation.read more
Citations
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Posted ContentDOI
Shared and distinct brain regions targeted for immediate early gene expression by ketamine and psilocybin
TL;DR: By identifying regions with similar and disparate effects, the results provide insights into how psilocybin and ketamine may produce their rapid-acting and long-lasting therapeutic effects.
Journal ArticleDOI
Shared and Distinct Brain Regions Targeted for Immediate Early Gene Expression by Ketamine and Psilocybin
TL;DR: In this article , the authors employed whole-brain serial two-photon microscopy and light sheet microscopy to map the expression of the immediate early gene, c-Fos, in male and female mice.
Journal ArticleDOI
Crocin ameliorates depressive-like behaviors induced by chronic restraint stress via the NAMPT-NAD+-SIRT1 pathway in mice
TL;DR: Zhang et al. as mentioned in this paper investigated the effects of crocin on depression induced by chronic restraint stress (CRS) in mice and found that crocin ameliorated depressive-like behaviors, which manifested by increased sucrose consumption ratio and decreased immobility time in FST and TST.
Top-Down Projections of the Prefrontal Cortex to the Ventral Tegmental Area, Laterodorsal Tegmental Nucleus, and Median Raphe Nucleus
Rudieri Souza,Debora Bueno,Leandro B. Lima,Luciano de Souza Gonçalves,Jose Donato,Sara J. Shammah-Lagnado,Martin Metzger +6 more
TL;DR: The findings reveal a broadly similar set of prefrontal afferents to VTA, LDTg, and MnR, further supporting an eminent functional role of the PFC as a controller of all major state setting mesopontine modulatory transmitter systems.
References
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Journal ArticleDOI
Global, regional, and national incidence, prevalence, andyears lived with disability for 354 diseases and injuries for195 countries and territories, 1990–2017: a systematicanalysis for the Global Burden of Disease Study 2017
Gbd Disease,Injury Incidence,Lorenzo Monasta,Luca Ronfani,Ettore Beghi,Giorgia Giussani,Boris Bikbov,Norberto Perico,Cristina Bosetti,Monica Cortinovis,Silvano Gallus,Giuseppe Remuzzi +11 more
TL;DR: All-cause age-standardised YLD rates decreased by 3·9% from 1990 to 2017; however, the all-age YLD rate increased by 7·2% while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100).
Journal ArticleDOI
The molecular neurobiology of depression
TL;DR: Recent studies combining behavioural, molecular and electrophysiological techniques reveal that certain aspects of depression result from maladaptive stress-induced neuroplastic changes in specific neural circuits and show that understanding the mechanisms of resilience to stress offers a crucial new dimension for the development of fundamentally novel antidepressant treatments.
Journal ArticleDOI
Lateral habenula as a source of negative reward signals in dopamine neurons
TL;DR: It is shown that the primate lateral habenula, part of the structure called the epithalamus, is a major candidate for a source of negative reward-related signals in dopamine neurons, and the inhibitory input from the lateral ha benula plays an important role in determining the reward- related activity of dopamine neurons.
Journal ArticleDOI
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
TL;DR: Findings highlight the central importance of homeostatic control of mood circuit connections and form the basis of a synaptogenic hypothesis of depression and treatment response.
Journal ArticleDOI
A standardized protocol for repeated social defeat stress in mice
TL;DR: A protocol whereby C57BL/6J mice that are repeatedly subjected to bouts of social defeat by a larger and aggressive CD-1 mouse results in the development of a clear depressive-like syndrome, characterized by enduring deficits in social interactions.
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