Hypothermia-induced retrograde amnesia: Role of body temperature in memory retrieval
TLDR
The relationship of body temperature to the onset, and the subsequent alleviation, of hypothermia-induced retrograde amnesia (RA) was investigated and the possibility of different mechanisms underlying retention after Hypothermia and retrieval after recooling was suggested.Abstract:
The relationship of body temperature to the onset, and the subsequent alleviation, of hypothermia-induced retrograde amnesia (RA) was investigated. In Experiment 1, the retention of a passive avoidance task and the body temperature at the time of testing were assessed at intervals of 4, 8, 12, and 16 h after training/amnesic treatment. While retention was evident for up to 12 h posthypothermia treatment, it was clear that body temperature did not index magnitude of RA. A second experiment examined the alleviation of hypothermia-induced RA as a function of body temperature and retention interval. Memory recovery was facilitated at both 1- and 7-day intervals when testing occurred at 29°-31°C but not at 33°–35°C. The possibility of different mechanisms underlying retention after hypothermia and retrieval after recooling was suggested. An alternative explanation in terms of contextual cues and cue utilization was also discussed.read more
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Persistent Disruption of a Traumatic Memory by Postretrieval Inactivation of Glucocorticoid Receptors in the Amygdala
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Integration of New Information with Active Memory Accounts for Retrograde Amnesia: A Challenge to the Consolidation/Reconsolidation Hypothesis?
Pascale Gisquet-Verrier,Joseph F. Lynch,Pasquale Cutolo,Daniel Toledano,Adam Richard Ulmen,Aaron M. Jasnow,David C. Riccio +6 more
TL;DR: It is shown that new/reactivated memories can be formed without protein synthesis and that amnesia can be induced by drugs that do not affect protein synthesis, and the findings more likely support the integration hypothesis.
References
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Time-dependent processes in memory storage
TL;DR: The findings indicate that the long-lasting trace of an experience is not completely fixed, consolidated, or coded at the time of the experience, and that any search for the engram or the basis of memory is not going to be successful.