Journal ArticleDOI
ICPEMC working paper 4/2 extrapolations from species to species and from various cell types in assessing risks from chemical mutagens
TLDR
In this article, the authors use extrapolations of dose: mutation ratios in other species to estimate human mutation frequencies, based on extrapolation of dose-dependent mutation ratios of other species.Abstract:
Strategies for estimating human mutation frequencies can be based on extrapolations of dose: mutation ratios in other species.read more
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Book ChapterDOI
Zebrafish in Toxicology and Environmental Health.
Kathryn Bambino,Jaime Chu +1 more
TL;DR: This work focuses on areas where zebrafish have been most effectively used in ecotoxicology and in environmental health, including investigation of exposures to endocrine disruptors, industrial waste byproducts, and arsenic.
Journal ArticleDOI
Interpreting human genetic variation with in vivo zebrafish assays.
TL;DR: This article will review the use of this model organism in dissecting human genetic disorders; how diverse strategies have informed disease causality and genetic architecture are highlighted; and relative strengths and limitations of these approaches in the context of medical genome sequencing are discussed.
Report on the consensus workshop on formaldehyde
M. Gough,R. Hart,B.W. Karrh,A. Koestner,R. Neal,D. Parkinson,F. Perera,K.E. Powell,S. Rosenkranz +8 more
TL;DR: The Consensus Workshop on Formaldehyde consisted of bringing together scientists from academia, government, industry and public interest groups to address some important toxicological questions concerning the health effects of formaldehyde.
Journal ArticleDOI
A personal history
TL;DR: In this paper, the authors present a book about the history of the National Academy of Sciences and its role in the creation of the first computer vision system, the Neural Network (NMS).
Journal ArticleDOI
Activation of mutagens by hepatocytes and liver 9000 X g supernatant from human origin in the Salmonella typhimurium mutagenicity assay. Comparison with rat liver preparations.
TL;DR: Comparison of the mutagenicity data obtained with the human liver preparations with those obtained with rat liver preparations showed great interspecies differences in the capacity to activate certain chemicals into mutagens.
References
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Journal ArticleDOI
Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test
TL;DR: The methods described include the standard plate test, the use and storage of the bacterial tester strains, preparation and use of the liver homogenates, and the methods of inducing the rats for elevated microsomal enzyme activity.
Journal ArticleDOI
Production of clones of homozygous diploid zebra fish ( Brachydanio rerio )
TL;DR: Clones of homozygous fish have been produced from individual homozygotes and associated genetic methods facilitate genetic analyses of this vertebrate.
Journal ArticleDOI
Short-term tests for carcinogens and mutagens
Journal ArticleDOI
Quantitative Correlation of Relative Rates. Comparison of Hydroxide Ion with Other Nucleophilic Reagents toward Alkyl Halides, Esters, Epoxides and Acyl Halides1
Journal ArticleDOI
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse
TL;DR: Use of the specific-locus test to measure the frequency of transmitted gene mutations induced in mouse spermatogonia has shown ethylnitrosourea to be by far the most potent mutagen yet discovered in the mouse.