Journal ArticleDOI
Imaging superficial tissues with polarized light.
Reads0
Chats0
TLDR
In this paper, the transition of linearly polarized light into randomly polarized light during light propagation through tissues was studied in polystyrene microsphere solutions, in chicken muscle (breast) and liver, and in porcine muscle and skin.Abstract:
Objective
Polarized light can be used to obtain images of superficial tissue layers such as skin, and some example images are presented. This study presents a study of the transition of linearly polarized light into randomly polarized light during light propagation through tissues.
Study Design/Materials and Methods
The transition of polarization was studied in polystyrene microsphere solutions, in chicken muscle (breast) and liver, and in porcine muscle and skin. The transition is discussed in terms of a diffusion process characterized by an angular diffusivity (radians2/mean free path) for the change in angular orientation of linearly polarized light per unit optical path traveled by the light.
Results
Microsphere diffusivity increased from 0.031 to 0.800 for diameters decreasing from 6.04 μm to 0.306 μm, respectively. Tissue diffusivity varied from a very low value (0.0004) for chicken liver to an intermediate value (0.055) for chicken and porcine muscle to a very high value (0.78) for pig skin.
Conclusion
The results are consistent with the hypothesis that birefringent tissues randomize linearly polarized light more rapidly than nonbirefringent tissues. The results suggest that polarized light imaging of skin yields images based only on photons backscattered from the superficial epidermal and initial papillary dermis because the birefringent dermal collagen rapidly randomizes polarized light. This anatomic region of the skin is where cancer commonly arises. Lasers Surg. Med. 26:119–129, 2000. © 2000 Wiley-Liss, Inc.read more
Citations
More filters
Journal ArticleDOI
Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry
TL;DR: This review is an attempt to indicate which sets of phantoms are optimal for specific applications, and provide links to studies that characterize main phantom material properties and recipes.
Journal ArticleDOI
Imaging skin pathology with polarized light
TL;DR: This paper compares normal light images, represented by I(per), and Pol images of various skin pathologies in a pilot clinical study using incoherent visible-spectrum light and suggests that the point spread function in skin for cross-talk between Pol pixels has a half-width-half-max of about 390 microm.
Journal ArticleDOI
Optical properties of normal and cancerous human skin in the visible and near-infrared spectral range.
TL;DR: In this spectral region, the scattering of cancerous lesions is consistently lower than that of normal tissues, whereas absorption does not differ significantly, with the exception of nodular basal cell carcinomas (BCC).
Journal ArticleDOI
Tissue polarimetry: concepts, challenges, applications, and outlook
TL;DR: A summary of issues pertinent to the polarized light methodologies in tissues, including polarized light basics, Stokes-Muller formalism, methods of polarization measurements, polarized light modeling in turbid media, applications to tissue imaging, inverse analysis for polarimetric results quantification, Applications to quantitative tissue assessment, etc.
Patent
Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
TL;DR: In this paper, a method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (LCI) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies, is presented.
References
More filters
BookDOI
Optical-Thermal Response of Laser-Irradiated Tissue
TL;DR: Welch et al. as discussed by the authors proposed a Monte Carlo Modeling of Light Transport in Tissue S.C. van Gemert, A.J. van Leeuwen, et al., and C.C., Svaasand.
Journal ArticleDOI
Optical polarization imaging
TL;DR: A novel technique is demonstrated for noninvasive surface and beneath-the-surface imaging of biological systems using parallel and perpendicular polarization components of a light pulse backscattered from a scattering medium.
Journal ArticleDOI
Use of polarized light to discriminate short-path photons in a multiply scattering medium
TL;DR: Results of Monte Carlo simulations and experiments show that if the scattering anisotropy of the scatterers is sufficiently small, absorbing barriers embedded in optically dense suspensions of polystyrene spheres can be resolved with good contrast by selectively detecting a component of the scattered-light intensity that has preserved its incident circular polarization state.
Journal ArticleDOI
Polarized light examination and photography of the skin.
TL;DR: Viewing skin through a linear polarizer, under linearly polarized illumination, separates the two components of tissue reflectance, and an enhanced view of vasculature and pigmented lesions is obtained.
Journal ArticleDOI
Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions.
TL;DR: Experiments on polystyrene-sphere and Intralipid suspensions demonstrate that the radial and azimuthal variations of the observed pattern depend on the concentration, size, and anisotropy factor g of the particles that constitute the scattering medium.