Journal ArticleDOI
Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder.
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TLDR
It is suggested that the increased activity of pro- inflammatory cytokines and an imbalance between pro-inflammatory and anti-inflammatory cytokines may play a role in the pathophysiology of bipolar disorder.About:
This article is published in Journal of Affective Disorders.The article was published on 2007-12-01. It has received 346 citations till now. The article focuses on the topics: Mood stabilizer & Bipolar disorder.read more
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Journal ArticleDOI
Pathways underlying neuroprogression in bipolar disorder : focus on inflammation, oxidative stress and neurotrophic factors
Michael Berk,Flávio Kapczinski,Ana Cristina Andreazza,Ana Cristina Andreazza,Olivia M Dean,Olivia M Dean,Francesco Giorlando,Francesco Giorlando,Michael Maes,Murat Yücel,Clarissa Severino Gama,Seetal Dodd,Seetal Dodd,Brian Dean,Brian Dean,Pedro Vieira da Silva Magalhães,Pedro Vieira da Silva Magalhães,G. Paul Amminger,Patrick D. McGorry,Gin S Malhi +19 more
TL;DR: Emerging data shows that these biomarkers may differ between early and late stages of BD in parallel with stage-related structural and neurocognitive alterations, which facilitates identification of rational therapeutic targets, and the development of novel treatment classes.
Journal ArticleDOI
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
Michael Maes,Raz Yirmyia,Jens Noraberg,Stefan Brené,Joe Hibbeln,Giulia Perini,Marta Kubera,Petr Bob,Bernard Lerer,Mario Maj +9 more
TL;DR: Screening for inflammatory and neurodegenerative processes in depression will allow to discover new I&ND biomarkers, both at the level of gene expression and the phenotype, and elucidate the underlying molecular I &ND pathways causing depression; identify new therapeutic targets in the I& ND pathways; develop new anti-I&ND drugs for these targets; and select existingAnti-I &ND drugs or substances that could augment the efficacy of antidepressants.
Journal ArticleDOI
Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies
TL;DR: A meta-analysis of studies comparing cytokine concentrations between patients with bipolar disorder (BD) and healthy control subjects (HCs) provides evidence for significant elevation of proinflammatory, anti-inflammatory, and regulatory cytokines in BD.
Journal ArticleDOI
Inflamed moods: a review of the interactions between inflammation and mood disorders.
TL;DR: This synthetic review is to review the evidence for an association between inflammation and mood disorders, to discuss potential pathophysiologic mechanisms that may explain this association and to present novel therapeutic options currently being investigated that target the inflammatory-mood pathway.
Journal ArticleDOI
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder.
Márcia Kauer-Sant'Anna,Márcia Kauer-Sant'Anna,Flávio Kapczinski,Ana Cristina Andreazza,Ana Cristina Andreazza,David J. Bond,Raymond W. Lam,L. Trevor Young,Lakshmi N. Yatham +8 more
TL;DR: Examination of cytokine and BDNF levels in bipolar I disorder patients found that failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these have the potential to serve as markers of illness progression in BD.
References
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Journal ArticleDOI
Cytokines and major depression.
TL;DR: Although the central effects of proinflammatory cytokines appear to be able to account for most of the symptoms occurring in depression, it remains to be established whether cytokines play a causal role in depressive illness or represent epiphenomena without major significance.
Journal ArticleDOI
Evidence for an immune response in major depression: a review and hypothesis
TL;DR: It is hypothesized that increased monocytic production of interleukins (Il-1 beta and Il-6) in severe depression may constitute key phenomena underlying the various aspects of the immune and "acute" phase response, while contributing to hypothalamic-pituitary-adrenal-axis hyperactivity, disorders in serotonin metabolism, and to the vegetative symptoms of severe depression.
Journal ArticleDOI
Increased serum il-6 and il-1 receptor antagonist concentrations in major depression and treatment resistant depression
TL;DR: Major depression and TRD are accompanied by an activation of the monocytic arm of cell-mediated immunity, and the latter may be related to the immune an acute phase response in major depression; and the above disorders may persist despite successful antidepressive treatment.
Related Papers (5)
Pathways underlying neuroprogression in bipolar disorder : focus on inflammation, oxidative stress and neurotrophic factors
Michael Berk,Flávio Kapczinski,Ana Cristina Andreazza,Ana Cristina Andreazza,Olivia M Dean,Olivia M Dean,Francesco Giorlando,Francesco Giorlando,Michael Maes,Murat Yücel,Clarissa Severino Gama,Seetal Dodd,Seetal Dodd,Brian Dean,Brian Dean,Pedro Vieira da Silva Magalhães,Pedro Vieira da Silva Magalhães,G. Paul Amminger,Patrick D. McGorry,Gin S Malhi +19 more