Journal ArticleDOI
Impact of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass on HbA1c Blood Level and Pharmacological Treatment of Type 2 Diabetes Mellitus in Severe or Morbidly Obese Patients. Results of a Multicenter Prospective Study at 1 Year
David Nocca,Fabre Guillaume,Patrick Noel,Marie Christine Picot,Rajesh Aggarwal,Moez El Kamel,Roxanne Schaub,Charles de Seguin de Hons,Eric Renard,Jean Michel Fabre +9 more
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TLDR
LSG seems to be as effective as LGBP for the management of T2DM in severely obese patients at 1 year after surgery, and during short-term follow-up, the impact on regulation of HbA1c blood level of L GBP or LSG is important.Abstract:
Gastric bypass (GBP) has proved its efficacy 30 years ago in the management of diabetes mellitus (T2DM) for severe obese patients. More recently, interesting results have been published after sleeve gastrectomy (SG) in the same indication. Between 2005 and 2008, three bariatric centers have prospectively collected the data of T2DM patients treated by laparoscopic gastric bypass (LGBP) or laparoscopic sleeve gastrectomy (LSG). Effects on hemoglobin A1c (HbA1c), pharmacological treatment and excess weight loss after 1 year of surgery have been analyzed. All patients (35 LGBP and 33 LSG) were treated with oral anti-diabetics (OAD) or insulin before surgery (32 OAD and three insulin in LGBP group and 27 OAD and six insulin in LSG group). The average body mass index (BMI) in the LGBP group was 47.9 and 50.6 kg/m² in the LSG group. At 1 year after surgery, the average HbA1c lost was 2,537 in the GBP group and 2,175 in the SG group. T2DM had resolved (withdrawal of pharmacological treatment) in 60% of the LGBP group and 75.8% of the LSG group. Reduced use of pharmacological therapy was noted in 31.42% of the LGBP group and 15.15% of the LSG group. Percentage excess weight loss and BMI lost were 56.35% and 29.75% in the LGBP group and 60.11% and 29.80% in the LSG group, respectively. During short-term follow-up, the impact on regulation of HbA1c blood level of LGBP or LSG is important. At 1 year after surgery, LSG seems to be as effective as LGBP for the management of T2DM in severely obese patients.read more
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Journal ArticleDOI
Clinical Practice Guidelines for the Perioperative Nutritional, Metabolic, and Nonsurgical Support of the Bariatric Surgery Patient—2013 Update: Cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery
Jeffrey I. Mechanick,Adrienne Youdim,Daniel B. Jones,W. Timothy Garvey,Daniel L. Hurley,M. Molly McMahon,Leslie J. Heinberg,Robert F. Kushner,Ted D. Adams,Scott A. Shikora,John Dixon,Stacy A. Brethauer +11 more
TL;DR: These updated guidelines reflect recent additions to the evidence base and include Examples of expanded topics in this update include: the roles of sleeve gastrectomy, bariatric surgery in patients with type‐2 diabetes,bariatric surgery for patients with mild obesity, copper deficiency, informed consent, and behavioral issues.
Journal ArticleDOI
Clinical Practice Guidelines for the Perioperative Nutritional, Metabolic, and Nonsurgical Support of the Bariatric Surgery Patient—2013 Update: Cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery
Jeffrey I. Mechanick,Adrienne Youdim,Daniel B. Jones,W. Timothy Garvey,Daniel L. Hurley,M. Molly McMahon,Leslie J. Heinberg,Robert F. Kushner,Ted D. Adams,Scott A. Shikora,John Dixon,Stacy A. Brethauer +11 more
TL;DR: These updated guidelines reflect recent additions to the evidence base and include Examples of expanded topics in this update include: the roles of sleeve gastrectomy, bariatric surgery in patients with type-2 diabetes,bariatric surgery for patients with mild obesity, copper deficiency, informed consent, and behavioral issues.
Journal ArticleDOI
Third International Summit: current status of sleeve gastrectomy
TL;DR: According to the questionnaire, presentations, and debates, the weight loss and improvement in diabetes appear to be better than with laparoscopic adjustable gastric banding and on par with Roux-en-Y gastric bypass.
Journal ArticleDOI
Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease
TL;DR: The physiological functions of both glucagon and GLP-1 are discussed by comparing and contrasting how these peptides function, variably in concert and opposition, to regulate glucose and energy homeostasis.
Journal ArticleDOI
Position of the Academy of Nutrition and Dietetics: Interventions for the Treatment of Overweight and Obesity in Adults
TL;DR: Current data and recommendations for the treatment of overweight and obesity in adults are presented and evidence on intrapersonal influences, such as dietary approaches, lifestyle intervention, pharmacotherapy, and surgery, are provided.
References
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Journal ArticleDOI
Lifestyle, Diabetes, and Cardiovascular Risk Factors 10 Years after Bariatric Surgery
TL;DR: A prospective, controlled Swedish Obese Subjects Study involved obese subjects who underwent gastric surgery and contemporaneously matched, conventionally treated obese control subjects, which reported follow-up data for subjects who had been enrolled for at least 2 years or 10 years before the analysis.
Journal ArticleDOI
Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus.
Walter J. Pories,Melvin Swanson,Kenneth G. MacDonald,Stuart B. Long,Patricia G. Morris,Brenda M. Brown,Hisham A. Barakat,Richard A. deRamon,Jeanette M. Dolezal,G. Lynis Dohm +9 more
TL;DR: The gastric bypass operation provides long-term control of non-insulin-dependent diabetes mellitus (NIDDM) and antidiabetic effects appear to be due primarily to a reduction in caloric intake, suggesting that insulin resistance is a secondary protective effect rather than the initial lesion.
Journal ArticleDOI
Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis.
Henry Buchwald,Rhonda Estok,Kyle Fahrbach,Deirdre Banel,Michael D. Jensen,Walter J. Pories,John P. Bantle,Isabella Sledge +7 more
TL;DR: In this paper, the impact of bariatric surgery on type 2 diabetes in association with the procedure performed and the weight reduction achieved was determined. But, the authors focused on the resolution of the clinical and laboratory manifestations of Type 2 diabetes.
Journal ArticleDOI
Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.
John Dixon,Paul E. O'Brien,Julie Playfair,Leon Chapman,Linda M. Schachter,Stewart Skinner,Joseph Proietto,Michael Bailey,Margaret Louise Anderson +8 more
TL;DR: People randomized to surgical therapy were more likely to achieve remission of type 2 diabetes through greater weight loss, and these results need to be confirmed in a larger, more diverse population and have long-term efficacy assessed.
Journal ArticleDOI
Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study
TL;DR: The markedly reduced ghrelin levels in addition to increased PYY levels after LSG, are associated with greater appetite suppression and excess weight loss compared with LRYGBP.
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Lifestyle, Diabetes, and Cardiovascular Risk Factors 10 Years after Bariatric Surgery
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Lars Sjöström,Kristina Narbro,C. David Sjöström,Kristjan Karason,B Larsson,Hans Wedel,Theodore Lystig,Marianne Sullivan,Claude Bouchard,Björn Carlsson,Calle Bengtsson,Sven Dahlgren,Anders Gummesson,Peter Jacobson,Jan Karlsson,Anna Karin Lindroos,Hans Lönroth,Ingmar Näslund,Torsten Olbers,Kaj Stenlöf,Jarl S Torgerson,Göran Ågren,Lena M. S. Carlsson +22 more