Journal ArticleDOI
Impaired Muscle Strength in Female Adolescents and Young Adults Surviving Leukemia in Childhood
TLDR
To evaluate late sequelae of childhood leukemia, the muscle strength of 43 young female survivors was investigated and compared with that of 69 healthy age‐matched women.Abstract:
Background. With the improving cure rate in childhood malignancies, increasing interest has been focused on long-term survivors. To evaluate late sequelae of childhood leukemia, the muscle strength of 43 young female survivors was investigated and compared with that of 69 healthy age-matched women. The patients had been off therapy for 1 to 19 years.
Methods. The anthropometric characteristics measured were height and weight, and body mass index was calculated. The maximal isometric strengths for elbow flexion, knee extension, and hand grip were measured on a special dynamometer chair. Dynamic muscular endurance was measured by pushup and situp tests.
Results. The mean height of the patients was 6.5 cm shorter (P < 0.001) and their mean weight 4.8 kg lighter (P = 0.011) than that of the reference subjects. Muscle strength was in most tests poorer in the patients than in the reference subjects. The differences were statistically significant in elbow flexion and knee extension, and in both muscular endurance tests. There was an association between the maximal isometric strengths and the anthropometric characteristics. Even when allowance was made for the smaller size of the patients, however, they still had less muscle strength than the reference subjects. Of the various treatment modalities, radiation therapy to the cranial area and chemotherapy with L-aspara-ginase were independently associated with the lower muscle strength values.
Conclusions. The muscle strength of female patients may be subnormal for many years after therapy for childhood leukemia. To compensate for these deficiencies, the possible benefits of prophylactic and individually planned exercise should be studied. Cancer 1993; 72:276–81.read more
Citations
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Journal ArticleDOI
Muscle Strength and Body Mass Index as Long-Term Predictors of Mortality in Initially Healthy Men
Taina Rantanen,Tamara B. Harris,Suzanne G. Leveille,M. Visser,M. Visser,Daniel J. Foley,Kamal Masaki,Jack M. Guralnik +7 more
TL;DR: In healthy middle-aged men, long-term mortality risk was associated with grip strength at baseline, independent of BMI, and the possible interpretation of the finding is that early life influences on muscle strength may have long- term implications for mortality.
Journal ArticleDOI
Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics.
Rae Ellen W. Kavey,Vivek Allada,Stephen R. Daniels,Laura L. Hayman,Brian W. McCrindle,Jane W. Newburger,Rulan S. Parekh,Julia Steinberger +7 more
TL;DR: In this article, a panel of experts reviewed what is known about very premature cardiovascular disease in 8 high-risk pediatric diagnoses and, from the science base, developed practical recommendations for management of cardiovascular risk.
Journal ArticleDOI
Muscle strength, disability and mortality.
TL;DR: Midlife grip strength was also found to predict long‐term total mortality: those with poorer strength at baseline were more likely to die over the follow‐up period of 30 years.
Journal ArticleDOI
Effects of physical therapy intervention for children with acute lymphoblastic leukemia
TL;DR: The purpose of this study was to examine the effects of physical therapy intervention in children with acute lymphoblastic leukemia (ALL).
Journal ArticleDOI
Physical exercise training interventions for children and young adults during and after treatment for childhood cancer.
Katja I. Braam,Patrick van der Torre,Tim Takken,Margreet A. Veening,Eline van Dulmenâ€den Broeder,Gertjan J.L. Kaspers +5 more
TL;DR: This is an update of the original review that was performed in 2011 and included five studies that compared the effects of physical exercise training with no training, in people who were within the first five years of their diagnosis of childhood cancer.
References
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Journal ArticleDOI
Muscular strength profiles and anthropometry in random samples of men aged 31–35, 51–55 and 71–75 years
TL;DR: Grip strength was found to have the highest correlation with chronological age and to be least affected by the body anthropometric variables among the strength variables studied.
Journal ArticleDOI
Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia
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