Journal ArticleDOI
In vivo evaluation of time and site of disintegration of polysaccharide tablet prepared for colon-specific drug delivery.
TLDR
In this paper, a compression coating with 150mg of granules containing a mixture of xanthan (XG), guar gum (GG) and starch was used for colonic drug delivery.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2005-01-31. It has received 57 citations till now. The article focuses on the topics: Dosage form & Guar gum.read more
Citations
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Journal ArticleDOI
Solventless pharmaceutical coating processes: a review.
Sagarika Bose,Robin H. Bogner +1 more
TL;DR: Six solventless coating methods—compression coating, hot-melt coating, supercritical fluid spray coating, electrostatic coating, dry powder coating, and photocurable coating—that can be used to coat the pharmaceutical dosage forms are discussed and compared.
Journal ArticleDOI
Optimization of 5-flurouracil solid-lipid nanoparticles: a preliminary study to treat colon cancer.
Alaa Eldeen B. Yassin,Md. Khalid Anwer,Hammam A. Mowafy,Ibrahim M. El-Bagory,Mohsen A. Bayomi,Ibrahim A. Alsarra +5 more
TL;DR: DSC and FTIR results suggested the existence of the lipids in the solid crystalline state of 5-flurouracil inside the colonic medium for local treatment of colon cancer.
Journal ArticleDOI
Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora
TL;DR: Alternative dissolution approaches have been designed to better represent the colonic conditions, such as utilizing polysaccharide-degrading enzymes, rat caecal contents, human fecal slurries, and multi-stage culture systems.
Journal ArticleDOI
Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives.
Niranjan G. Kotla,Shubhasmin Rana,Gandhi Sivaraman,Omprakash Sunnapu,Praveen Kumar Vemula,Abhay Pandit,Yury Rochev,Yury Rochev +7 more
TL;DR: The present review focuses on major physiological gastro-intestinal tract challenges involved in altering the pharmacokinetics of delivery systems, pathophysiology of MH and fibrosis, reported drug-polysaccharide cargos and focusing on conventional to advanced disease responsive delivery strategies, highlighting their limitations and future perspectives in intestinal inflammation therapy.
Journal ArticleDOI
In vitro evaluations of konjac glucomannan and xanthan gum mixture as the sustained release material of matrix tablet
TL;DR: The experimental results predicted that the polysaccharide mixtures of konjac glucomannan and xanthan gum has a good potential to be applied to sustained release drug delivery systems.
References
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Journal ArticleDOI
In vitro evaluation of guar gum as a carrier for colon-specific drug delivery
TL;DR: The results illustrate the usefulness of guar gum as a potential carrier for colon-specific drug delivery and reveal that the use of 4% w/v of rat caecal contents in PBS, obtained after 7 days of enzyme induction provide the best conditions for in vitro evaluation of Guar gum.
Journal ArticleDOI
Amylose as a coating for drug delivery to the colon: Preparation and in vitro evaluation using 5-aminosalicylic acid pellets
S. Milojevic,JM Newton,John H. Cummings,Glenn R. Gibson,R. Louise Botham,Stephen G. Ring,Mike Stockham,M. C. Allwood +7 more
TL;DR: Colon-specific drug delivery may be possible by the application of dried amylose films to pharmaceutical formulations byorporation of insoluble polymers into the amylOSE film, to controlAmylose swelling, of which a commercially available ethylcellulose (Ethocel®) was found to control the swelling most effectively.
Journal ArticleDOI
Colonic Drug Targeting
TL;DR: The anatomy and physiology of the lower gastrointestinal tract are surveyed and the biopharmaceutical aspects are considered in relation to drug absorption in the colon and hence various approaches to colon-specific drug delivery are discussed.
Journal ArticleDOI
Relationship between swelling, erosion and drug release in hydrophillic natural gum mini-matrix formulations.
TL;DR: Fickian drug diffusion and polymer erosion were both occurring simultaneously in mini-matrices produced with drug:gum ratios of 1:1 as well as formulations of drug and X in combinations of 2:1, 2:3 and 1:2.
Related Papers (5)
Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation
Pharmaceutical approaches to colon targeted drug delivery systems.
Manish K. Chourasia,Sanjay Jain +1 more