In vivo spatially localized high resolution 1H MRS via intermolecular single‐quantum coherence of rat brain at 7 T
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TLDR
To compare the conventional localized point‐resolved spectroscopy (PRESS) with localized 2D intermolecular single‐quantum coherence (iSQC) magnetic resonance spectroscopic (MRS) and obtain in vivo MRS spectrum of rat brain using the latter technique.Abstract:
Purpose:
To compare the conventional localized point-resolved spectroscopy (PRESS) with localized 2D intermolecular single-quantum coherence (iSQC) magnetic resonance spectroscopy (MRS) and obtain in vivo MRS spectrum of rat brain using the latter technique.
Materials and Methods:
A brain phantom, an intact pig brain tissue, and mature Sprague–Dawley rat were studied by PRESS, Nano magic-angle spinning spectroscopy, and iSQC MRS.
Results:
Using PRESS, high-resolution MRS can be obtained from the brain phantom and pig brain tissue with a small voxel in a relatively homogeneous field. When a large voxel is selected, the field homogeneity is distinctly reduced. No useful information is obtained from the PRESS spectra. However, using the iSQC MRS, high-resolution spectra can be obtained from the two samples with a relatively large voxel. In the same way, an iSQC MRS spectrum can be obtained from a relatively large voxel of in vivo rat brain with a comparable resolution to the PRESS spectrum with a small voxel.
Conclusion:
Compared to PRESS, the iSQC MRS may be more feasible and promising for detection of strongly structured tissues with relatively large voxels. J. Magn. Reson. Imaging 2013;37:359–364. © 2012 Wiley Periodicals, Inc.read more
Citations
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High-resolution NMR spectroscopy in inhomogeneous fields
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Spatially Localized Two-Dimensional J-Resolved NMR Spectroscopy via Intermolecular Double-Quantum Coherences for Biological Samples at 7 T.
TL;DR: The localized iDQCJRES method holds advantage for recovering high-resolution 2D J-resolved information from inhomogeneous fields caused by external non-ideal field condition or internal macroscopic magnetic susceptibility variations in biological samples, and it is free of voxel size limitation and time-consuming field shimming procedure.
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High Resolution Nuclear Magnetic Resonance Spectroscopy on Biological Tissue and Metabolomics.
TL;DR: Broadband 1H homodecoupled NMR spectroscopy displays J coupled resonances as collapsed singlets, resulting in highly resolved spectra, which can be used to acquire high-resolution spectra of some pharmaceuticals.
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Improved WATERGATE Pulse Sequences for Solvent Suppression in NMR Spectroscopy
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