Journal ArticleDOI
Incidence of cancer in 98 patients with common varied immunodeficiency.
Charlotte Cunningham-Rundles,Frederick P. Siegal,Susanna Cunningham-Rundles,Philip H. Lieberman +3 more
TLDR
Patients with common varied immunodeficiency have been observed for periods of 1–13 years, showing an 8- to 13-fold increase in cancer in general for patients who have this immunODeficiency and a 438-fold rise in lymphoma for females.Abstract:
Ninety-eight patients with common varied immunodeficiency have been observed for periods of 1–13 years. In 1986, 78 were alive, 19 had died, and 1 could not be located. Eleven patients in the group had developed cancer; two patients had had two cancers. Of the total number of neoplastic malignancies, seven were non-Hodgkin's lymphoma, one patient had a Waldenstrom's macroglobulinemia, and nine of the patients who developed cancer were female. Cancer developed in the fifth or sixth decade of life for 10 of the 11 patients. These data show an 8- to 13-fold increase in cancer in general for patients who have this immunodeficiency and a 438-fold increase in lymphoma for females.read more
Citations
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Journal ArticleDOI
Common variable immunodeficiency: clinical and immunological features of 248 patients
TL;DR: In this article, the authors describe the clinical and immunological status of 248 consecutively referred CVI patients of age range 3-79 years who have been followed for a period of 1-25 years.
Journal ArticleDOI
Morbidity and mortality in common variable immune deficiency over 4 decades.
TL;DR: Mortality was associated with lymphoma, any form of hepatitis, functional or structural lung impairment, and gastrointestinal disease with or without malabsorption, but not with bronchiectasis, autoimmunity, other cancers, granulomatous disease, or previous splenectomy.
Journal ArticleDOI
Clinical and immunologic analyses of 103 patients with common variable immunodeficiency.
TL;DR: In this article, the authors analyzed 103 consecutively referred CVI patients of age range 3-71 years (average, 29 years) who were followed for a period of 1-13 years (total of 750 patient years).
Journal ArticleDOI
Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia
TL;DR: Patients with CVID and XLAG manifest a spectrum of abnormalities in the gastrointestinal tract, with patterns superficially resembling graft-versus-host disease, inflammatory bowel disease, and Whipple's disease, but often lacking some of the diagnostic features of the diseases.
Journal ArticleDOI
How I treat common variable immune deficiency.
TL;DR: This review presents the approach to the diagnosis and treatment of patients with common variable immunodeficiency, with suggestions for the use of laboratory biomarkers and means of monitoring patients.
References
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Journal ArticleDOI
Fundamentals of Biostatistics.
E. Barath,B. A. Rosner +1 more
TL;DR: Bernard Rosner's FUNDAMENTALS of BIOSTATISTICS is a practical introduction to the methods, techniques, and computation of statistics with human subjects that prepares students for their future courses and careers.
Book
Fundamentals of Biostatistics
TL;DR: Bernard Rosner's "Fundamentals of BIOSTATISTICS" as mentioned in this paper is a practical introduction to the methods, techniques, and computation of statistics with human subjects.
Journal ArticleDOI
Idiopathic late-onset immunoglobulin deficiency: Clinical observations in 50 patients
TL;DR: Men and women were equally affected, although the age at onset in men peaked in the third decade whereas it was more uniformly distributed in women, and a high degree of susceptibility to neoplasia was noted.
Journal ArticleDOI
Prospective study of cancer in patients with hypogammaglobulinaemia.
TL;DR: Among 377 patients with primary hypogammaglobulinaemia, mainly common variable immunodeficiency (CVID), 316 patients survived the first 2 years after diagnosis and were the subject of a study of cancer incidence.
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