Journal ArticleDOI
Indium(III) chloride-catalyzed one-pot synthesis of dihydropyrimidinones by a three-component coupling of 1,3-dicarbonyl compounds, aldehydes, and urea: an improved procedure for the Biginelli reaction.
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This article is published in Journal of Organic Chemistry.The article was published on 2000-09-22. It has received 421 citations till now. The article focuses on the topics: Biginelli reaction & Indium(III) chloride.read more
Citations
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Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog.
TL;DR: This Account highlights recent developments in the Biginelli reaction in areas such as solid-phase synthesis, combinatorial chemistry, and natural product synthesis.
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Solvent-free heterocyclic synthesis.
TL;DR: 1. Six-Membered Heterocycles with One Heteroatom 4155 7.6.1.
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Utilisation of 1,3‐Dicarbonyl Derivatives in Multicomponent Reactions
TL;DR: In this article, an overview of the potential of 1,3-dicarbonyl derivatives for the selective construction of highly functionalised small organic molecules of high synthetic and biological value is presented.
Journal ArticleDOI
Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis
TL;DR: In this paper, the authors summarized the results reported mainly within the last 10 years, and it is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis.
Journal ArticleDOI
Indium(III) bromide-catalyzed preparation of dihydropyrimidinones: improved protocol conditions for the Biginelli reaction
TL;DR: In this article, a new protocol for the Biginelli reaction was proposed, which produces excellent yields, allows the recycling of catalyst with no loss in its activity, and leads to zero-discharge during the process.
References
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Journal ArticleDOI
Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents.
Karnail Atwal,Brian N. Swanson,Steven E. Unger,Floyd David M,Suzanne Moreland,Anders Hedberg,Brian C. O'Reilly +6 more
TL;DR: The results demonstrate that the active R-(-)-enantiomer 20a of 7 is both more potent and longer acting than nifedipine (1) as an antihypertensive agent in the SHR.
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Unprecedented Catalytic Three Component One-Pot Condensation Reaction: An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones
TL;DR: Biginelli's initial one-pot reflux of â-keto ester 2, aryl aldehyde 3, and urea, 4, with catalytic acid in a protic solvent frequently afforded low (20-50%) yields as mentioned in this paper.
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Substituted 1,4-dihydropyrimidines. 3. Synthesis of selectively functionalized 2-hetero-1,4-dihydropyrimidines
TL;DR: Par reactions electrophiles selectives sur les [p-anisilyloxy-2- ou p -anisylthio-2 dihydro-1,4 nitro-3'phenyl-4 methyl-6] pyrimidinecarboxylates-5 d'ethyle.
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A revision of the Biginelli reaction under solid acid catalysis. Solvent-free synthesis of dihydropyrimidines over montmorillonite KSF
TL;DR: In this paper, the reaction of aldehydes, β-dicarbonyl compounds and urea (Biginelli reaction) has been performed over solid acid catalysis, under solventless conditions or in water affording dihydropyrimidines in good yield and selectivity.