Journal ArticleDOI
Individual Responsiveness to a Cholesterol-Lowering Diet in Postmenopausal Women with Moderate Hypercholesterolemia
TLDR
In this article, a step-1 diet for postmenopausal women with hypercholesterolemia was shown to reduce LDL cholesterol levels by 0.36 mmol/L (14 mg/dL).Abstract:
Background: The efficacy of the step 1 diet in outpatient women with hypercholesterolemia has been debated. Methods: Forty-one normotriglyceridemic women whose low-density lipoprotein (LDL) cholesterol levels were 3.62 to 5.17 mmol/L (140 to 200 mg/dL) participated in a twoperiod outpatient diet counseling study that used a 1-month high-fat, high-saturated fatty acid period (Hi-Sat diet) and a 4-month low-fat, low-saturated fatty acid period (step 1 diet). All women were postmenopausal and were not taking hormone replacement therapy. Levels of lipids, lipoproteins, and plasma triglyceride fatty acids were measured five times during the last 2 weeks of each dietary period. Dietary intake was assessed by 7-day food records. Results: The mean reduction in total cholesterol level achieved by the step 1 diet was 0.36 mmol/L (14 mg/ dL). The reduction in total cholesterol level was seen in both LDL cholesterol levels (0.28 mmol/L [11 mg/dL];P Conclusions: A step 1 diet lowers total and LDL cholesterol levels in postmenopausal women. A nonsignificant reduction in high-density lipoprotein cholesterol levels was also observed. Since some women achieved LDL cholesterol levels low enough to obviate the need for drug therapy as primary prevention of coronary heart disease, dietary therapy should remain the first step in the management of hypercholesterolemia in postmenopausal women. (Arch Intern Med. 1994;154:1977-1982)read more
Citations
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Journal ArticleDOI
Effects of Reducing Dietary Saturated Fatty Acids on Plasma Lipids and Lipoproteins in Healthy Subjects The Delta Study, Protocol 1
Henry N. Ginsberg,Penny M. Kris-Etherton,Barbara H. Dennis,Patricia J. Elmer,Abby G. Ershow,Michael Lefevre,Thomas A. Pearson,Paul S. Roheim,Rajasekhar Ramakrishnan,Roberta G. Reed,Kent K. Stewart,Paul W. Stewart,Katherine M. Phillips,Nancy Anderson +13 more
TL;DR: In a well-controlled feeding study, stepwise reductions in SFA resulted in parallel reductions in plasma total and LDL cholesterol levels, indicating that diet can have a significant impact on risk for atherosclerotic cardiovascular disease in the total population.
Annals of Internal Medicine Cost-Effectiveness of Cholesterol-Lowering Therapies according to Selected Patient Characteristics
Lisa A. Prosser,Aaron A. Stinnett,Paula A. Goldman,Lawrence W. Williams,Lee Goldman,Milton C. Weinstein +5 more
TL;DR: The cost-effectiveness of primary and secondary prevention with cholesterol-lowering therapies was evaluated in separate risk subgroups to assess how cost- effectiveness varies with individual patient characteristics, and improves on previous analyses by including updated costs and epidemiologic estimates.
Journal ArticleDOI
Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile : studies in the fasting and postprandial states
Lars Berglund,Lars Berglund,Michael Lefevre,Henry N. Ginsberg,Penny M. Kris-Etherton,Patricia J. Elmer,Paul W. Stewart,Abby G. Ershow,Thomas A. Pearson,Barbara H. Dennis,Paul S. Roheim,Rajasekhar Ramakrishnan,Roberta G. Reed,Kent K. Stewart,Katherine M. Phillips +14 more
TL;DR: In the study population, who were at increased risk of coronary artery disease, MUFA provided a greater reduction in risk as a replacement for saturated fat than did carbohydrate.
Journal ArticleDOI
What is the desirable ratio of saturated, polyunsaturated, and monounsaturated fatty acids in the diet?
TL;DR: Although further research is needed to determine a recommended ratio of oleic acid to carbohydrates, on the basis of the relatively low rates of coronary artery disease and cancer in both the Mediterranean region and in populations consuming low-fat, high-carbohydrate diets, a reasonable compromise is a diet in which total fat is approximately 30% of energy, allowing for an intake of ooleic acid of 15-16% of total energy.
Journal ArticleDOI
Very low fat diets.
TL;DR: The writers fail to recognize that a low-fat diet does not cause triglycerides to rise if the fat is replaced by unrefined, complex carbohydrates, naturally high in fiber, as reviewed by Anderson et al.
References
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Journal ArticleDOI
Effects of Reducing Dietary Saturated Fatty Acids on Plasma Lipids and Lipoproteins in Healthy Subjects The Delta Study, Protocol 1
Henry N. Ginsberg,Penny M. Kris-Etherton,Barbara H. Dennis,Patricia J. Elmer,Abby G. Ershow,Michael Lefevre,Thomas A. Pearson,Paul S. Roheim,Rajasekhar Ramakrishnan,Roberta G. Reed,Kent K. Stewart,Paul W. Stewart,Katherine M. Phillips,Nancy Anderson +13 more
TL;DR: In a well-controlled feeding study, stepwise reductions in SFA resulted in parallel reductions in plasma total and LDL cholesterol levels, indicating that diet can have a significant impact on risk for atherosclerotic cardiovascular disease in the total population.
Annals of Internal Medicine Cost-Effectiveness of Cholesterol-Lowering Therapies according to Selected Patient Characteristics
Lisa A. Prosser,Aaron A. Stinnett,Paula A. Goldman,Lawrence W. Williams,Lee Goldman,Milton C. Weinstein +5 more
TL;DR: The cost-effectiveness of primary and secondary prevention with cholesterol-lowering therapies was evaluated in separate risk subgroups to assess how cost- effectiveness varies with individual patient characteristics, and improves on previous analyses by including updated costs and epidemiologic estimates.
Journal ArticleDOI
Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile : studies in the fasting and postprandial states
Lars Berglund,Lars Berglund,Michael Lefevre,Henry N. Ginsberg,Penny M. Kris-Etherton,Patricia J. Elmer,Paul W. Stewart,Abby G. Ershow,Thomas A. Pearson,Barbara H. Dennis,Paul S. Roheim,Rajasekhar Ramakrishnan,Roberta G. Reed,Kent K. Stewart,Katherine M. Phillips +14 more
TL;DR: In the study population, who were at increased risk of coronary artery disease, MUFA provided a greater reduction in risk as a replacement for saturated fat than did carbohydrate.
Journal ArticleDOI
What is the desirable ratio of saturated, polyunsaturated, and monounsaturated fatty acids in the diet?
TL;DR: Although further research is needed to determine a recommended ratio of oleic acid to carbohydrates, on the basis of the relatively low rates of coronary artery disease and cancer in both the Mediterranean region and in populations consuming low-fat, high-carbohydrate diets, a reasonable compromise is a diet in which total fat is approximately 30% of energy, allowing for an intake of ooleic acid of 15-16% of total energy.
Journal ArticleDOI
Very low fat diets.
TL;DR: The writers fail to recognize that a low-fat diet does not cause triglycerides to rise if the fat is replaced by unrefined, complex carbohydrates, naturally high in fiber, as reviewed by Anderson et al.
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