Journal ArticleDOI
Insulin resistance and oxidative marker in women with PCOS.
TLDR
It is suggested that women with PCOS have oxidative stress and elevated CRP irrespective of obesity, however, hyperinsulinemia and Insulin resistance are seen only in obese women withPCOS, indicating that these women are at high risk for developing low grade inflammation and cardiovascular diseases.Abstract:
Polycystic Ovary Syndrome is a multifactorial reproductive problem and a leading cause of female infertility worldwide. Evidences have shown that Oxidative Stress and decreased antioxidant status a...read more
Citations
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Journal ArticleDOI
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing
H. Sadeghi,I. Adeli,Daniela Calina,Anca Oana Docea,Taraneh Mousavi,Marzieh Daniali,Shekoufeh Nikfar,Aristidis Tsatsakis,Mohammad Abdollahi +8 more
TL;DR: Understanding more about PCOS would be beneficial to find new medications implying the effect via the novel discovered routes, and it would be helpful to do further research and run well-designed clinical trials on this subject.
Journal ArticleDOI
Uric acid participating in female reproductive disorders: a review.
TL;DR: Uric acid (UA) is the end metabolic product of purine metabolism and has been found to be associated with many diseases, including kidney disease and cardiovascular disease as discussed by the authors, but there is still a paucity of reviews on the association between UA and the female reproductive system.
Journal ArticleDOI
The Disorders of Endometrial Receptivity in PCOS and Its Mechanisms.
Nan-Xing Jiang,Xue-Lian Li +1 more
TL;DR: In this article, the authors focused on the disorders of endometrial receptivity of patients with polycystic ovary syndrome (PCOS) and analyzed the possible mechanisms of decreased endometrium receptivity and its relationship with the main endocrine and metabolic disorders of PCOS such as hyperandrogenism, inflammation, insulin resistance and obesity.
Journal ArticleDOI
Immune Regulation in Polycystic Ovary Syndrome.
TL;DR: In this article , the authors summarize the immune regulation involved in the pathogenesis of polycystic ovarian syndrome (PCOS) and pave the way for the development of better PCOS treatment options in the near future.
Journal ArticleDOI
Polycystic ovary syndrome is a risk factor for sarcopenic obesity: a case control study
TL;DR: Women with PCOS have a high prevalence of sarcopenic obesity, which is correlated to insulin resistance and inflammation, and vitamin D is thought to positively affect skeletal muscle mass.
References
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Journal ArticleDOI
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
TL;DR: PCO women have significant insulin resistance that is independent of obesity, changes in body composition, and impairment of glucose tolerance, and PCO is associated with a unique disorder of insulin action.
Journal ArticleDOI
Role of oxidative stress in female reproduction
TL;DR: The role OS plays in normal cycling ovaries, follicular development and cyclical endometrial changes is reviewed and female infertility and how it influences the outcomes of assisted reproductive techniques is discussed.
Journal ArticleDOI
Adipose Tissue-Derived Factors: Impact on Health and Disease
TL;DR: The endocrine functions of the adipose organ are widely studied at this stage and the systemic impact of adipocyte-derived factors on energy homeostasis is discussed.
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Lifestyle changes in women with polycystic ovary syndrome
TL;DR: Lifestyle intervention improves body composition, hyperandrogenism (high male hormones and clinical effects) and insulin resistance in women with PCOS, and provided benefits when compared to minimal treatment for secondary reproductive, anthropometric and reproductive outcomes.
Journal ArticleDOI
Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: role of insulin sensitivity and luteinizing hormone.
TL;DR: It is concluded that lifestyle modification without rapid weight loss leads to a reduction of central fat and improved insulin sensitivity, which restores ovulation in overweight infertile women with PCOS.