Journal ArticleDOI
Integration of biological monitoring, environmental monitoring and computational modelling into the interpretation of pesticide exposure data: introduction to a proposed approach
Claudio Colosio,Federico Maria Rubino,Athanasios Alegakis,E. Ariano,Gabri Brambilla,Stefan Mandić-Rajčević,Francesca Metruccio,Claudio Minoia,Angelo Moretto,C. Somaruga,Aristidis Tsatsakis,Roberta Turci,F. Vellere +12 more
TLDR
Based on the combination of toxicity indices and exposure indices it is possible to obtain semiquantitative estimates of the risk levels experienced by the workers in the exposure scenarios considered, and a proof of principle example of this approach is the subject of this article.About:
This article is published in Toxicology Letters.The article was published on 2012-08-13. It has received 28 citations till now. The article focuses on the topics: Environmental exposure & Environmental monitoring.read more
Citations
More filters
Journal ArticleDOI
Occupational exposure to pesticides as a possible risk factor for the development of chronic diseases in humans (Review).
Silvia Gangemi,Edoardo Miozzi,Michele Teodoro,Giusi Briguglio,Annamaria De Luca,Carmela Alibrando,Irene Polito,Massimo Libra +7 more
TL;DR: This review summarises the most recent findings describing the association between pesticide occupational exposure and the development of chronic diseases.
Journal ArticleDOI
Six months exposure to a real life mixture of 13 chemicals' below individual NOAELs induced non monotonic sex-dependent biochemical and redox status changes in rats.
Anca Oana Docea,Eliza Gofita,Marina Goumenou,Daniela Calina,Otilia Constantina Rogoveanu,Marius Ciprian Varut,Cristian Olaru,Efthalia Kerasioti,Polyxeni Fountoucidou,Ioannis Taitzoglou,Ovidiu Zlatian,Valerii N. Rakitskii,Antonio F. Hernández,Dimitrios Kouretas,Aristidis Tsatsakis +14 more
TL;DR: Adverse effects were observed on body weight gain and in hepatotoxic parameters such as the total bilirubin, alanine aminotransferase (ALT) and alkaline phosphatase (ALP), especially in low dose and affecting mainly male rats.
Journal ArticleDOI
Genotoxic, cytotoxic, and cytopathological effects in rats exposed for 18 months to a mixture of 13 chemicals in doses below NOAEL levels
Aristidis Tsatsakis,Anca Oana Docea,Carolina Constantin,Daniela Calina,Ovidiu Zlatian,Taxiarchis Konstantinos Nikolouzakis,Polychronis Stivaktakis,Alexandra Kalogeraki,Jyrki Liesivuori,George N. Tzanakakis,Monica Neagu +10 more
TL;DR: Investigation of the genotoxic and cytotoxic effects of long term exposure to low doses of a mixture consisting of methomyl, triadimefon, dimethoate, glyphosate, carbaryl, methyl parathion, aspartame, sodium benzoate, EDTA, ethylparaben, buthylparABen, bisphenol A and acacia gum in rats results in conclusion.
Journal ArticleDOI
Toxicology for real-life risk simulation - Editorial preface to this special issue.
TL;DR: The present special issue is intended to collect key articles and pioneering studies in support of this new area of toxicology, acknowledging the need for a paradigm shift of the current approaches for risk assessment towards a Real-Life Risk Simulation (RLRS) approach.
Journal ArticleDOI
The dose response principle from philosophy to modern toxicology: The impact of ancient philosophy and medicine in modern toxicology science.
Aristidis Tsatsakis,Loukia Vassilopoulou,Leda Kovatsi,Christina Tsitsimpikou,Marianna Karamanou,G. Leon,Jyrki Liesivuori,A. W. Hayes,Demetrios A. Spandidos +8 more
TL;DR: The concept of dose response traces back to 8th century BC, with Hesiod’s Harmonia, and Bernard stated the dose response concept, Cushny, Harnack & Ehrlich formulated threshold and minimal effective dose terms.
References
More filters
Journal ArticleDOI
Regional variation in percutaneous penetration in man. Pesticides
TL;DR: The forearm was used as the frame reference, and the palm, of which the thick stratum corneum is allegedly almost impenetrable, allowed approximately the same penetration as the forearm.
Journal ArticleDOI
A Quantitative Approach for Estimating Exposure to Pesticides in the Agricultural Health Study
Mustafa Dosemeci,Michael C. R. Alavanja,Andrew S. Rowland,David T. Mage,Shelia Hoar Zahm,Nathaniel Rothman,Jay H. Lubin,Jane A. Hoppin,Dale P. Sandler,Aaron Blair +9 more
TL;DR: A quantitative method to estimate long-term chemical-specific pesticide exposures in a large prospective cohort study of more than 58000 pesticide applicators in North Carolina and Iowa found that the take-home questionnaire sub-cohort of applicators is representative of the entire cohort in terms of exposure.
The placing of plant protection products on the market
TL;DR: In this paper, Dinu and Karamfilova conducted a European Implementation Assessment (EIA) on the implementation of the European Food Safety Directive (EC) 1107/2009 and found that despite the implementation challenges observed, stakeholders including national competent authorities, health/environment NGOs, manufacturers of substances and plant protection products and their users (farmers), agree that the EU is the appropriate level at which regulatory action in the field of pesticides (used in plant protection product) should continue to take place.
Journal ArticleDOI
Pesticide contamination of workers in vineyards in France
TL;DR: A field study in Bordeaux vineyards during the 2001 and 2002 treatment seasons to identify parameters related to external contamination of workers and types of equipment influenced significantly the daily contamination.
Journal ArticleDOI
In vivo percutaneous absorption and decontamination of pesticides in humans.
TL;DR: The principles of percutaneous absorption--the rate and extent that chemicals enter the body through the skin--using data currently available for pesticides are reviewed.