Journal ArticleDOI
Interaction between DNA and an Escherichia coli protein ω
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TLDR
It appears that ω is capable of introducing a “swivel” reversibly into a DNA, and a plausible mechanism is postulated.About:
This article is published in Journal of Molecular Biology.The article was published on 1971-02-14. It has received 696 citations till now. The article focuses on the topics: A-DNA & DNA.read more
Citations
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Cellular roles of DNA topoisomerases: a molecular perspective.
TL;DR: In this review, the cellular roles of these enzymes are examined from a molecular point of view.
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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.
TL;DR: This review focuses on the molecular and biochemical characteristics of topoisomerases and their inhibitors and discusses the common mechanism of action ofTopoisomerase poisons by interfacial inhibition and trapping of topisomerase cleavage complexes.
Journal ArticleDOI
Biochemistry of homologous recombination in Escherichia coli.
TL;DR: This review focuses on the biochemical mechanisms underlying these steps, with particular emphases on the activities of the proteins involved and on the integration of these activities into likely biochemical pathways for recombination.
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DNA gyrase: an enzyme that introduces superhelical turns into DNA
TL;DR: Relaxed closed-circular DNA is converted to negatively supercoiled DNA by DNA gyrase by purified from Escherichia coli cells, and the final superhelix density of the DNA can be considerably greater than that found in intracellularly super coiled DNA.
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Etoposide: four decades of development of a topoisomerase II inhibitor
TL;DR: The history of the development of one of the first identified topoisomerase II inhibitors, etoposide, is reviewed and critical developments in etopose's mechanism of action, pharmacology and administration schedule are summarised.
References
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Journal ArticleDOI
The interaction of closed circular DNA with intercalative dyes. I. The superhelix density of SV40 DNA in the presence and absence of dye
William Bauer,Jerome Vinograd +1 more
TL;DR: The binding results have allowed us to estimate the dependence of the sedimentation coefficient of SV40 I DNA upon the number of superhelical turns in the presence of dye, and that SV40 DNA contains about −13 superhelicals turns in concentrated salt solutions.
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Physical and topological properties of circular DNA.
Jerome Vinograd,Jacob Lebowitz +1 more
TL;DR: Several types of circular DNA molecules are now known, which are classified as single-stranded rings, covalently closed duplex rings, and weakly bonded Duplex rings containing an interruption in one or both strands.
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Interaction of closed circular DNA with intercalative dyes. II. The free energy of superhelix formation in SV40 DNA.
William Bauer,Jerome Vinograd +1 more
TL;DR: It is shown in the present paper that the binding to nicked circular SV40 DNA may be described by an intercalation model in which every region between adjoining base pairs is a potential binding site, with the restriction that no two adjoining sites may be occupied.
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Partial denaturation of thymine- and 5-bromouracil-containing λ DNA in alkali
Ross B. Inman,Maria Schnös +1 more
TL;DR: An electron microscopic examination of λ DNA, partially denatured at high pH, shows that the sections which denature first are at the same positions as those previously observed for λDNA partially den atured by heat.
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Variation of the average rotation angle of the DNA helix and the superhelical turns of covalently closed cyclic λ DNA
TL;DR: Studies on cyclic bacteriophage λb2b5c DNA covalently closed in vitro by Escherichia coli polynucleotide joining enzyme reveal the following: the DNA helix unwinds slightly as the temperature is increased at temperatures 60 to 100 deg.