Journal ArticleDOI
Interaction of protein and zinc malnutrition with the murine response to infection.
Reads0
Chats0
TLDR
It is concluded that protein malnutrition is the dominant factor influencing weight loss and mortality in this model, however, zinc malnutrition does shorten the length of survival and may contribute to the global immunosuppression noted in malnourished subjects.Abstract:
Malnutrition increases the host's susceptibility to infection. However, the mechanisms are not well understood. This study examined the interaction of protein and zinc underfeeding in mice before challenge with an intracellular pathogen, Salmonella typhimurium. C3H/HeN mice (n = 68) were weighted and placed on one of four diets: 20% ovalbumin with adequate zinc (20% NL), 20% ovalbumin without zinc (20% LO), 1% ovalbumin with zinc (1% NL), and 1% ovalbumin without zinc (1% LO). At the end of 6 weeks they were again weighed and then challenged with 10(4) S. typhimurium intraperitoneally. Mortality was recorded over the next 2 weeks. Although weight loss was markedly affected by protein malnutrition (two-way analysis of variance: p = .0001), there was no independent effect by zinc (p = .3459). Similarly, protein malnutrition alone affected mortality rates (chi 2: p = .0001), whereas zinc had no independent effect (p = .7166). However, both protein and zinc underfeeding shortened the length of survival (Mann-Whitney U test: p less than .001). We conclude that protein malnutrition is the dominant factor influencing weight loss and mortality in this model. However, zinc malnutrition does shorten the length of survival and may contribute to the global immunosuppression noted in malnourished subjects.read more
Citations
More filters
Journal ArticleDOI
Nutrition and the immune system: a review of nutrient-nutrient interactions.
TL;DR: Although research on the role of single nutrients in immune function is extensive, this is not the case for multiple nutrients and subsequent nutrient-nutrient interactions.
Journal ArticleDOI
Serum zinc and copper status in hospitalized vs. healthy elderly subjects.
Slimane Belbraouet,Hughes Biaudet,Ambroise Tébi,Nearkasèn Chau,Katherine Gray-Donald,Gérard Debry +5 more
TL;DR: The significantly lower values of serum zinc found in the hospitalized elderly compared to healthy elderly are likely to be related to disease rather than to aging per se, and copper/zinc ratio may be a useful marker of malnutrition.
Journal ArticleDOI
Dietary effects of faba-bean (Vicia faba L.) tannins on the morphology and function of the small-intestinal mucosa of weaned pigs
TL;DR: The morphological variables of the mucosa of the three groups of piglets were similar and no changes due to dietary tannins were observed in sucrase, and activity in homogenates of mucosa plus submucosa was significantly lower than that in the animals fed on the control diet or the diet with low-tannin hulls.
Book ChapterDOI
Early Enteral Feeding Improves Outcome
G. P. Zaloga,P. R. Roberts +1 more
TL;DR: Nutrients supply substrates required for the replication of cells, generation of second messengers, maintenance of cellular barriers, destruction of invading pathogens, and detoxification of oxidants.
Journal ArticleDOI
Zincémie, cuprémie et infection chez l'enfant malnutri
F. Khaldi,A. Ben Mansour,Abderrazek Hedhili,Neziha Kaabachi,N Gueddana,A. Mebazaa,B Ben Naceur +6 more
TL;DR: Infection increases the risk of low serum zinc and copper concentrations seen in malnourished children, and this factor must be taken in account when treating malnutrition.
References
More filters
Journal ArticleDOI
Prevalence of malnutrition in general medical patients.
TL;DR: Compared with a similar survey among surgical patients, the medical patients were more depleted calorically but had better protein status (arm-muscle circumference, serum albumin) than the non-medical patients, which is likely to be associated with diminished cell-mediated immunity.
Journal ArticleDOI
Protein Status of General Surgical Patients
TL;DR: In a survey of the protein nutritional status of all patients on the surgical wards of an urban municipal hospital, accepted standards indicated moderate to severe protein-calorie malnutrition in one half of these patients as judged by triceps skin fold and arm muscle circumference measurements.
Journal ArticleDOI
Percentage of weight loss: basic indicator of surgical risk in patients with chronic peptic ulcer
TL;DR: The general mortality rate among patients suffering from peptic ulcer has been materially reduced by surgical care and further observations on the sequence of events leading to this sustained rate are presented.
Journal ArticleDOI
Implications of Malnutrition in the Surgical Patient
TL;DR: The visceral protein compartment (serum albumin and serum transferrin levels and delayed hypersensitivity) is the most accurate prognostic indicator of postoperative morbidity and mortality.
Journal ArticleDOI
MALNUTRITION IN SURGICAL PATIENTS: An Unrecognised Problem
G L Hill,I. R. Pickford,G.A. Young,C.J. Schorah,R. L. Blackett,L Burkinshaw,J.V. Warren,D B Morgan +7 more
TL;DR: Indices of nutritional state were measured in surgical patients to give information on protein-calorie malnutrition, anaemia, vitamin deficiency, weight-loss, loss of arm-muscle bulk, and low plasma levels of transferrin and albumin.