Journal ArticleDOI
Interactions between mammalian cell DNA and inorganic platinum compounds. II. Interstrand cross-linking of isolated and cellular DNA by platinum(IV) compounds.
Janet M. Pascoe,John J. Roberts +1 more
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TLDR
It is unlikely that the ability of cis and trans Pt(IV)diammine tetrachloride to cross-link isolated or cellular DNA bears any relationship to their cytotoxic properties, and it is concluded that the differences seen in vitro and in vivo were approximately the same.About:
This article is published in Biochemical Pharmacology.The article was published on 1974-05-01. It has received 243 citations till now. The article focuses on the topics: Tetrachloride.read more
Citations
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Mechanisms of Cisplatin nephrotoxicity.
TL;DR: Recent advances in understanding of cisplatin nephrotoxicity are summarized and it is discussed how these advances might lead to more effective prevention.
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Mechanisms of resistance to cisplatin.
Maria Kartalou,John M. Essigmann +1 more
TL;DR: An improved understanding of the mechanisms of resistance operative in vivo has identified targets for intervention and may increase the utility of cisplatin for the treatment of cancer.
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The role of the unfolded protein response in tumour development: friend or foe?
Yanjun Ma,Linda M. Hendershot +1 more
TL;DR: Recent delineation of the components of this response indicate that it is uniquely poised to have a role in regulating the balance between cancer cell death, dormancy and aggressive growth, as well as altering the sensitivity of solid tumours to chemotherapeutic agents.
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Review of the Comparative Pharmacology and Clinical Activity of Cisplatin and Carboplatin
Ronald S. Go,Alex A. Adjei +1 more
TL;DR: Carboplatin does not possess equivalent activity to cisplatin in all platinum-sensitive tumors, and its role in limited-stage small-cell lung cancer needs to be investigated further.
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Exploration of the medical periodic table: towards new targets
TL;DR: Progress in identifying and defining target sites has been accelerated recently by advances in proteomics, genomics and metal speciation analysis, and examples of metal compounds and chelating agents (enzyme inhibitors) currently in clinical use, clinical trials or preclinical development are highlighted.
References
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Journal ArticleDOI
Platinum Compounds: a New Class of Potent Antitumour Agents
TL;DR: The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice and reversibly inhibit cell division in Gram-negative rods1–4.
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Defective repair replication of DNA in xeroderma pigmentosum.
TL;DR: Patients with xeroderma pigmentosum develop fatal skin cancers when exposed to sunlight, and so the failure of DNA repair in the skin must be related to carcinogenesis.
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The Inhibition of Growth or Cell Division in Escherichia coli by Different Ionic Species of Platinum(IV) Complexes
TL;DR: The cis and trans forms of the diamino complex, [PtCl4(NH3)2]0, have been synthesized and the electrophoretic patterns indicate predominantly neutral species in both cases.
Journal Article
The Successful Regression of Large Solid Sarcoma 180 Tumors by Platinum Compounds
TL;DR: In this paper, the platinum compounds, cisplatinum (IV) diamminotetrachloride and cis-platinum diamminodichloride, have been reported to be active in inhibiting and regressing small solid Sarcoma 180 tumors and Leukemia L1210 tumors in mice.
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Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in virtro.
TL;DR: A number of possible explanations for the greater sensitivity of DNA synthesis and the sequential inhibition of DNA, RNA and protein synthesis at higher concentrations are suggested.