Journal ArticleDOI
Interferon-α Generation in Mice Responding to Challenge with UV-Inactivated Herpes Simplex Virus
Tawfiqul Bhuiya,Michael Shodell,Patricia Fitzgerald-Bocarsly,Donna M. Murasko,Kokila Shah,Domenica Drake,Frederick P. Siegal +6 more
TLDR
In humans with advanced human immunodeficiency virus (HIV) infection, an interferon-α (IFN-α) response by a specialized blood mononuclear cell to herpes simplex virus (HSV) in vitro is in vitro.Abstract:
In humans with advanced human immunodeficiency virus (HIV) infection, an interferon-α (IFN-α) response by a specialized blood mononuclear cell to herpes simplex virus (HSV) in vitro is ass...read more
Citations
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Journal ArticleDOI
Regulation of IFN Regulatory Factor-7 and IFN-α Production by Enveloped Virus and Lipopolysaccharide in Human Plasmacytoid Dendritic Cells
TL;DR: It is demonstrated that both LPS and HSV up-regulate the expression of IRF-7 in PDC, and that this enhancement of IRf-7 is dependent on NF-κB activation, and suggests an activation required for IRF -7 that contributes to IFN-α production in virus-stimulated PDC.
Journal ArticleDOI
Natural Interferon-α Producing Cells: The Plasmacytoid Dendritic Cells
TL;DR: It is anticipated that a further understanding of the PDC will lead to the ability to specifically manipulate these cells in human disease, as well as their mechanisms of IFN-alpha induction and distribution.
Journal ArticleDOI
Depletion of T Cells by Type I Interferon: Differences between Young and Aged Mice
TL;DR: It is suggested that the lower level of functional IFN-αβ and decreased induction of active caspase-3 in T cells of aged mice after poly(I:C) may be responsible for the increased resistance of T cells in aged mice to depletion.
Journal ArticleDOI
Dendritic Cells Exposed to Herpes Simplex Virus In Vivo Do Not Produce IFN-α after Rechallenge with Virus In Vitro and Exhibit Decreased T Cell Alloreactivity
TL;DR: The data suggest HSV induces plasmacytoid dendritic cells maturation and at higher titers, exhaustion, diminishing T cell proliferation, and IFN-γ secretion.
Journal ArticleDOI
The interferon-alpha/beta responses of mice to herpes simplex virus studied at the blood and tissue level in vitro and in vivo.
TL;DR: The marginal zone IPCs may be the major source ofIFN in blood, and high splenic levels of IFN‐α/β should have efficient antiviral and immunoregulatory functions.
References
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Journal ArticleDOI
Genetics of natural resistance to herpesvirus infections in mice.
TL;DR: A mouse model is developed which has shown that at least three genes are responsible for resistance to HSV, and preliminary evidence suggests that resistance is immunologically mediated, but resistance genes do not seem to be closely linked to the histocompatibility region of the mouse.
Journal ArticleDOI
Severe Acquired Immune Deficiency Syndrome in Male Homosexuals: Diminished Capacity to Make Interferon-a in Vitro Associated with Severe Opportunistic Infections
TL;DR: Natural killer cell function, directed against either K562 tumor targets or herpes simplex virus type 1-infected fibroblasts, was often low in patients with acquired immune deficiency syndrome (AIDS) but failed to distinguish these patients from either male homosexual controls or patients with lymphadenopathy.
Journal ArticleDOI
Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity
Frederick P. Siegal,C Lopez,P.A. Fitzgerald,K. Shah,P Baron,I.Z. Leiderman,D. Imperato,S. Landesman +7 more
TL;DR: The data suggest that the AIDS virus affects a subset of LGL, and that cytokine production by these cells is an important component of the host defense against intracellular pathogens that becomes crucial in the presence of severe T cell immunodeficiency.
Journal Article
Dendritic cells and IFN-alpha-producing cells are two functionally distinct non-B, non-monocytic HLA-DR+ cell subsets in human peripheral blood.
Jihed Chehimi,Stuart E. Starr,H Kawashima,D S Miller,Giorgio Trinchieri,Bice Perussia,Santu Bandyopadhyay +6 more
TL;DR: At least two distinct HLA-DR+ cell subsets lacking surface markers specific for B cells, monocytes or other known lineages are present in human peripheral blood.
Journal ArticleDOI
Properties of human natural interferon-producing cells stimulated by tumor cell lines.
TL;DR: The IFN‐producing cells (IPC) in this system is characterized by cell separation procedures, including panning with different monoclonal antibodies, and two types of cells which were responsible for the IFN production could be identified.
Related Papers (5)
Alpha/Beta Interferon and Gamma Interferon Synergize To Inhibit the Replication of Herpes Simplex Virus Type 1
Bruno Sainz,William P. Halford +1 more