International Expert Opinions and Recommendations on the Use of Melatonin in the Treatment of Insomnia and Circadian Sleep Disturbances in Adult Neuropsychiatric Disorders
Laura Palagini,Raffaele Manni,Eugenio Aguglia,Mario Amore,Roberto Brugnoli,Stéphanie Bioulac,Patrice Bourgin,Patrice Bourgin,Jean Arthur Micoulaud Franchi,Paolo Girardi,Luigi Grassi,Régis Lopez,Claudio Mencacci,Giuseppe Plazzi,Julia Maruani,Antonino Minervino,Pierre Philip,Sylvie Royant Parola,Isabelle Poirot,Lino Nobili,Giovanni Biggio,Carmen M. Schröder,Carmen M. Schröder,Pierre A. Geoffroy +23 more
TLDR
In this paper, the authors conducted a systematic review according to PRISMA on the use of exogenous melatonin for the treatment of insomnia and circadian sleep disorders in neuropsychiatry.Abstract:
Introduction: Insomnia and circadian rhythm disorders, such as the delayed sleep phase syndrome, are frequent in psychiatric disorders and their evaluation and management in early stages should be a priority. The aim of this paper was to express recommendations on the use of exogenous melatonin, which exhibits both chronobiotic and sleep-promoting actions, for the treatment of these sleep disturbances in psychiatric disorders. Methods: To this aim, we conducted a systematic review according to PRISMA on the use of melatonin for the treatment of insomnia and circadian sleep disorders in neuropsychiatry. We expressed recommendations for the use of melatonin in psychiatric clinical practice for each disorder using the RAND/UCLA appropriateness method. Results: We selected 41 studies, which included mood disorders, schizophrenia, substance use disorders, attention deficit hyperactivity disorders, autism spectrum disorders, neurocognitive disorders, and delirium; no studies were found for both anxiety and eating disorders. Conclusion: The administration of prolonged release melatonin at 2-10 mg, 1-2 h before bedtime, might be used in the treatment of insomnia symptoms or comorbid insomnia in mood disorders, schizophrenia, in adults with autism spectrum disorders, neurocognitive disorders and during sedative-hypnotics discontinuation. Immediate release melatonin at <1 mg might be useful in the treatment of circadian sleep disturbances of neuropsychiatric disorders.read more
Citations
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Sleep, insomnia and mental health
TL;DR: The aim of this work was to link current understanding about insomnia mechanisms with current knowledge about mental health dysregulatory mechanisms, which represent important challenges in clinical practice on mood, anxiety, and psychotic disorders.
Journal ArticleDOI
Melatonin: From Neurobiology to Treatment.
Giovanni Biggio,Francesca Biggio,Giuseppe Talani,Maria Cristina Mostallino,Andrea Aguglia,Eugenio Aguglia,Laura Palagini +6 more
TL;DR: These properties of melatonin have allowed us to demonstrate in both experimental models and clinical studies the great chronobiotic efficacy and sleep promoting effects of exogenous melatonin.
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Melatonin Treatment for Sleep Disorders in Parkinson's Disease: A Meta-Analysis and Systematic Review
TL;DR: It is found that melatonin can significantly improve the subjective and objective sleep quality of patients with PD with good safety and tolerability, and could be considered an effective treatment for insomnia in patients withPD.
Journal ArticleDOI
Melatonin as a Chronobiotic with Sleep-promoting Properties
TL;DR: In this paper , a systematic and comprehensive review of the literature on the chronobiotic, sleep-inducing, and overall sleep-promoting properties of exogenous melatonin (exo-MEL) was conducted.
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Is SARS-CoV-2 a Risk Factor of Bipolar Disorder?—A Narrative Review
TL;DR: It is shown that disorders in COVID-19 showing the greatest similarity to those in BD are cytokine disorders, tryptophan metabolism, sleep disorders and structural changes in the central nervous system (CNS).
References
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Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
Journal Article
A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.
James Horne,Ostberg O +1 more
TL;DR: Although the questionnaire appears to be valid, further evaluation using a wider subject population is required, as sleep habits are an important déterminant of peak time there are other contibutory factors, and these appear to be partly covered by the questionnaire.
Journal ArticleDOI
Meta-analysis of sleep disturbance and suicidal thoughts and behaviors.
TL;DR: Sleep disturbances in general, as well as insomnia and nightmares individually, appear to represent a risk factor for suicidal thoughts and behavior, and this proposition is further bolstered by the result that depression did not show risk moderation.
Journal ArticleDOI
Insomnia as a predictor of mental disorders: A systematic review and meta-analysis.
Elisabeth Hertenstein,Bernd Feige,Tabea Gmeiner,Christian Kienzler,Kai Spiegelhalder,Anna F. Johann,Markus Jansson-Fröjmark,Laura Palagini,Gerta Rücker,Dieter Riemann,Chiara Baglioni +10 more
TL;DR: This meta-analysis provides evidence that insomnia increases the risk for psychopathology and calls for more prospective long-term interventional studies investigating the efficacy of insomnia treatment for the prevention of mental disorders.
Journal ArticleDOI
British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders.
Sue Wilson,David J. Nutt,Chris Alford,S. V. Argyropoulos,David S. Baldwin,A. N. Bateson,Thomas Bennett Britton,C. Crowe,D-J Dijk,Colin A. Espie,Paul Gringras,Göran Hajak,C. Idzikowski,Andrew D. Krystal,J. R. Nash,H. Selsick,Ann L. Sharpley,A. G. Wade +17 more
TL;DR: These British Association for Psychopharmacology guidelines are designed to address this problem by providing an accessible up-to-date and evidence-based outline of the major issues, especially those relating to reliable diagnosis and appropriate treatment.