Journal ArticleDOI
Intrarenal Pressure and Exaggerated Natriuresis in Essential Hypertension
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Intrarenal pressure, estimated by measurement of wedged renal vein pressure, was elevated in patients with essential hypertension, indicating that the higher systemic pressure in essential hypertension is transmitted beyond the arterioles and accounts for elevation of intrarenal Pressure.Abstract:
1. Intrarenal pressure, estimated by measurement of wedged renal vein pressure, was elevated in patients with essential hypertension. Despite increased afferent arteriolar resistance, glomerular pressure was elevated indicating that the higher systemic pressure in essential hypertension is transmitted beyond the arterioles and accounts for elevation of intrarenal pressure. 2. During hypertonic saline loading in hypertensives, renal arteriolar resistance falls, resulting in further increase in intrarenal pressure. Increments in intrarenal pressure paralleled increases in sodium excretion in patients with essential hypertension during the exaggerated natriuresis and in normotensive subjects after the prolonged infusion of hypertonic saline. 3. The marked increase in intrarenal pressure which appears to be responsible for exaggerated natriuresis in essential hypertension is attributable to an altered (exaggerated) response of the renal arterioles. The data suggest that elevated intrarenal pressure may play a role in the regulation of sodium balance in patients with essential hypertension.read more
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Journal ArticleDOI
Influence of renal capsule on kidney function in hypertension
J.F.G. Slegers,W. M. Moons +1 more
TL;DR: The results strongly suggest that the absolute values of the intrarenal pressures are not correlated with electrolyte excretion pattern; venous pressure elevation has a profound effect on electrolytes excretion rate only in SHR kidneys and in the decapsulated kidney of the WKY rat; and the capsular compliance in kidneys of SHR rats is higher.
Journal ArticleDOI
Feasibility of a balloon-occlusion technique for obtaining renal interstitial pressure.
Silverman Jf,Castellino Ra +1 more
TL;DR: Occlusion of a proximal interlobar vein with a balloon catheter can be used successfully to replace the wedging technique for determination of renal interstitial pressure.
Journal ArticleDOI
D-α-tocopherol reduces renal damage in hypertensive rats
TL;DR: It is suggested that D-α-tocopherol supplementation can reduce kidney damage induced by hypertension, and reduced the excretion of thiobarbituric acid-reactive substances (TBARS) in SHR.
Journal ArticleDOI
Natriuresis in the rhesus monkey after intracranial hypertension.
Journal ArticleDOI
[The importance of changes in whole-body balance of sodium and noradrenaline in essential hypertension (author's transl)].
TL;DR: It is concluded that whole-body balance of sodium and noradrenaline is an important factor in essential hypertension.