Journal ArticleDOI
Intrarenal Pressure and Exaggerated Natriuresis in Essential Hypertension
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Intrarenal pressure, estimated by measurement of wedged renal vein pressure, was elevated in patients with essential hypertension, indicating that the higher systemic pressure in essential hypertension is transmitted beyond the arterioles and accounts for elevation of intrarenal Pressure.Abstract:
1. Intrarenal pressure, estimated by measurement of wedged renal vein pressure, was elevated in patients with essential hypertension. Despite increased afferent arteriolar resistance, glomerular pressure was elevated indicating that the higher systemic pressure in essential hypertension is transmitted beyond the arterioles and accounts for elevation of intrarenal pressure. 2. During hypertonic saline loading in hypertensives, renal arteriolar resistance falls, resulting in further increase in intrarenal pressure. Increments in intrarenal pressure paralleled increases in sodium excretion in patients with essential hypertension during the exaggerated natriuresis and in normotensive subjects after the prolonged infusion of hypertonic saline. 3. The marked increase in intrarenal pressure which appears to be responsible for exaggerated natriuresis in essential hypertension is attributable to an altered (exaggerated) response of the renal arterioles. The data suggest that elevated intrarenal pressure may play a role in the regulation of sodium balance in patients with essential hypertension.read more
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Journal ArticleDOI
Renal parenchymal involvement in essential hypertension.
TL;DR: Effective treatment of severe and malignant hypertension clearly leads to stabilization (and occasionally improvement) of renal function, and this idea may have therapeutic implications for hypertensive patients with renal insufficiency in that agents that reduce both systemic and intraglomerular pressure may be preferable.
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Reduced renin activity in essential hypertension: a reappraisal.
TL;DR: Plasma renin activity fell with both increasing age and increasing arterial pressure, and was generally less in hypertensives, but small or absent responses were also seen in those with normal blood pressure.
Journal ArticleDOI
Sodium balance during development of hypertension in the spontaneously hypertensive rat (SHR).
Stefan Lundin,Hans Herlitz,Margareta Hallbäck‐Nordlander,Sven-Erik Ricksten,G. Göthberg,Göran Berglund +5 more
TL;DR: The present results do not support the concept that a primary renal retention of sodium and water should be of pathogenetic importance for the SHR variant of primary hypertension.
Journal ArticleDOI
Effect of sodium loading and exercise on renal haemodynamics and urinary sodium excretion in young patients with essential hypertension before and during propranolol treatment.
TL;DR: Urinary sodium excretion during sodium loading was significantly higher in the hypertensive patients than in the control subjects and decreased significantly during propranolol treatment, which may be related to functional or structural alterations in the renal vascular bed.
Journal ArticleDOI
How Do Antihypertensive Drugs Work? Insights from Studies of the Renal Regulation of Arterial Blood Pressure
TL;DR: These findings provide insights into the actions of antihypertensive drugs, and challenge misconceptions about the mechanisms underlying the therapeutic efficacy of many of the agents.